{"id":40162,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-neurotransmision-5-ht1a-en-corteza-frontal-de-rata-por-imipramina-vs-s-adenosil-l-metionina-en-el-tratamiento-agudo-y-cronico-correlacion-con-su-efecto-antidepresivo\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"modulacion-de-la-neurotransmision-5-ht1a-en-corteza-frontal-de-rata-por-imipramina-vs-s-adenosil-l-metionina-en-el-tratamiento-agudo-y-cronico-correlacion-con-su-efecto-antidepresivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-de-la-neurotransmision-5-ht1a-en-corteza-frontal-de-rata-por-imipramina-vs-s-adenosil-l-metionina-en-el-tratamiento-agudo-y-cronico-correlacion-con-su-efecto-antidepresivo\/","title":{"rendered":"Modulacion de la neurotransmision 5-ht1a en corteza frontal de rata por imipramina vs s.adenosil-l-metionina en el tratamiento agudo y cronico. correlacion con su efecto antidepresivo."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Nu\u00f1ez San Millan Carmen <\/strong><\/h2>\n<p>Imipramina es un antidepresivo que presenta este efecto s\u00f3lo tras un periodo de latencia y en relaci\u00f3n con la modificaci\u00f3n de la neurotransmisi\u00f3n 5-ht 1a de hipocampo de rata. Same, sin embargo presenta efecto antidepresivo tanto en tratamiento agudo como cr\u00f3nico, pero las modificaciones receptoriales s\u00f3lo aparecieron en \u00e9ste \u00faltimo. La asociaci\u00f3n de los dos f\u00e1rmacos origina un mayor efecto antidepresivo que ambos f\u00e1rmacos por separado en tratamiento agudo, corroborando el estudio cl\u00ednico realizado por berlanga en el que se demuestra que la asociaci\u00f3n same imipramina acelera la aparici\u00f3n del efecto antidepresivo de \u00e9sta. Esta asociaci\u00f3n s\u00f3lo muestra alteraciones receptoriales a nivel del hipocampo tras el tratamiento cr\u00f3nico. Para determinar si el efecto antidepresivo de same agudo y de la asociaci\u00f3n same-imipramina aguda se correlacionaba con modificaciones de la neurotransmisi\u00f3n 5-ht1a en otros n\u00facleos cerebrales nos planteamos los siguientes objetivos.  determinar si el tratamiento con imipramina en administraci\u00f3n aguda y cr\u00f3nica modifica las caracter\u00edsticas de los receptores 5-ht1a de la corteza frontal de rata, correlacionando este efecto con su acci\u00f3n antidepresiva.  determinar igualmente si el tratamiento agudo y cr\u00f3nico con same modifica la neurotransmisi\u00f3n serotonin\u00e9rgica 5-ht1a de la carteza frontal de rata, correlacionando su efecto con su acci\u00f3n antidepresiva. Y determinar si la asociaci\u00f3n de ambos f\u00e1rmacos modifica de forma similar al de ambos por separado, las caracter\u00edsticas de estos receptores.  se utiliz\u00f3 el siguiente material y m\u00e9todos, el trabajo se realiz\u00f3 empleando 64 ratas machos, raza wistar. Estos animales se dividieron en los siguientes grupos de tratamiento: grupo control, imipramina (10.9 mg\/kg), same (50 mg\/kg) y su asociaci\u00f3n, administrados durante 1 (tres administraciones) y 20 (una administraci\u00f3n) d\u00edas. En todos los animales se realizaron las siguientes experie<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion de la neurotransmision 5-ht1a en corteza frontal de rata por imipramina vs s.adenosil-l-metionina en el tratamiento agudo y cronico. correlacion con su efecto antidepresivo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion de la neurotransmision 5-ht1a en corteza frontal de rata por imipramina vs s.adenosil-l-metionina en el tratamiento agudo y cronico. correlacion con su efecto antidepresivo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Nu\u00f1ez San Millan Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Inmaculada Bellido Est\u00e9vez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Gonzalez baron <\/li>\n<li>carmen marina Alvarez garcia (vocal)<\/li>\n<li>margarita Prunel tuduri (vocal)<\/li>\n<li>francisca Rius d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nu\u00f1ez San Millan Carmen Imipramina es un antidepresivo que presenta este efecto s\u00f3lo tras un periodo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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