{"id":40182,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/monitorizacion-de-niveles-plasmaticos-de-antiepilepticos-relacion-nivel-eficacia-y-toxicidad\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"monitorizacion-de-niveles-plasmaticos-de-antiepilepticos-relacion-nivel-eficacia-y-toxicidad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/monitorizacion-de-niveles-plasmaticos-de-antiepilepticos-relacion-nivel-eficacia-y-toxicidad\/","title":{"rendered":"Monitorizacion de niveles plasmaticos de antiepilepticos: relacion nivel, eficacia y toxicidad."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rey Martin Ana Emilia <\/strong><\/h2>\n<p>Introducci\u00f3n, hip\u00f3tesis de trabajo y objetivos: la epilepsia es una enfermedad de elevada incidencia, cuyo abordaje terap\u00e9utico requiere la utilizaci\u00f3n de f\u00e1rmacos que presentan una complicada farmacocin\u00e9tica. Esta \u00faltima caracter\u00edstica hace que los f\u00e1rmacos antiepil\u00e9pticos presenten una gran cantidad de interacciones farmacol\u00f3gicas, a la vez que es frecuente observar la aparici\u00f3n de reacciones adversas tras su utilizaci\u00f3n. Estos motivos hacen que la monitorizaci\u00f3n de sus concentraciones plasm\u00e1ticas haya sido utilizada en los \u00faltimos 30 a\u00f1os como una importante herramienta en la terap\u00e9utica antiepil\u00e9ptica. Sin embargo, las condiciones y utilidad de la monitorizaci\u00f3n han sido ampliamente debatidas, existiendo serias discrepancias al respecto de su utilidad en el momento actual. Por este motivo, nos planteamos el presente trabajo con la finalidad de establecer: 1. Evaluar las pautas terap\u00e9uticas y los datos sobre monitorizaci\u00f3n de niveles plasm\u00e1ticos de antiepil\u00e9pticos, y 2. establecer la relaci\u00f3n entre los niveles plasm\u00e1ticos de estos f\u00e1rmacos y su eficacia y toxicidad.  metodolog\u00eda: se ha realizado un estudio observacional descriptivo y transversal con los 500 pacientes epil\u00e9pticos que fueron monitorizados en el servicio de farmacolog\u00eda cl\u00ednica del hospital universitario de m\u00e1laga. Se dise\u00f1\u00f3 un protocolo de recogida de datos que incluy\u00f3: datos antropom\u00e9tricos, caracter\u00edsticas de la epilepsia, pauta terap\u00e9utica, par\u00e1metros de monitorizaci\u00f3n, patolog\u00eda y medicaci\u00f3n concomitante, periodo sin crisis (como medida de evoluci\u00f3n cl\u00ednica) y reacciones adversas. el an\u00e1lisis estad\u00edstico comprendi\u00f3: an\u00e1lisis descriptivo, tablas de contingencia, an\u00e1lisis de varianza y an\u00e1lisis de regresi\u00f3n log\u00edstica m\u00faltiple.  resultados y discusi\u00f3n: los datos sobre caracter\u00edsticas de la enfermedad y terap\u00e9utica coinciden con otras series publicadas. Lo m\u00e1s destacado en nuestro estudio ha<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Monitorizacion de niveles plasmaticos de antiepilepticos: relacion nivel, eficacia y toxicidad.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Monitorizacion de niveles plasmaticos de antiepilepticos: relacion nivel, eficacia y toxicidad. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rey Martin Ana Emilia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez Correa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Garcia morillas <\/li>\n<li>Jos\u00e9 Pav\u00eda molina (vocal)<\/li>\n<li>pilar Fresen cansino (vocal)<\/li>\n<li> Fernandez sanchez m. carmen (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rey Martin Ana Emilia Introducci\u00f3n, hip\u00f3tesis de trabajo y objetivos: la epilepsia es una enfermedad de elevada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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