{"id":40198,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-de-silimarina-sobre-el-estatus-oxidativo-en-un-modelo-experimental-de-colestasis\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-del-efecto-de-silimarina-sobre-el-estatus-oxidativo-en-un-modelo-experimental-de-colestasis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-efecto-de-silimarina-sobre-el-estatus-oxidativo-en-un-modelo-experimental-de-colestasis\/","title":{"rendered":"Estudio del efecto de silimarina sobre el estatus oxidativo en un modelo experimental de colestasis."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gordillo Montoya Jos\u00e9 Manuel <\/strong><\/h2>\n<p>Las enfermedades hep\u00e1ticas representan un conjunto de patolog\u00edas muy importante y de gran frecuencia dentro de la cl\u00ednica humana. Un buen n\u00famero de \u00e9stas son procesos cr\u00f3nicos, con elevada morbilidad que conlleva importantes prestaciones asistenciales derivadas de su tratamiento sintom\u00e1tico y de la realizaci\u00f3n de costosas pruebas complementarias para su diagn\u00f3stico y seguimiento.  desde el punto de vista experimental, la colestasis representa un modelo v\u00e1lido de producci\u00f3n de da\u00f1o hep\u00e1tico, \u00fatil para la investigaci\u00f3n de afecciones por fallo hep\u00e1tico, as\u00ed como para la evaluaci\u00f3n de f\u00e1rmacos hepatoprotectores.  han sido muchas las patolog\u00edas relacionadas con un desequilibrio en la balanza del estatus oxidativo, entre ellas se encuentra la colestasis en la que encontramos con un incremento en la peroxidaci\u00f3n lip\u00eddica y una disminuci\u00f3n de las defensas antioxidantes con el consiguiente da\u00f1o celular.  muchos de los f\u00e1rmacos utilizados como hepatoprotectores presentan un posible mecanismo antioxidante. Uno de ellos es la silimarina.  de esta forma quisimos estudiar estos preparados valorando a la vez los dos platillos de la balanza del estatus oxidativo.  para ello, nos planteamos el presente trabajo con los siguientes objetivos:  &#8211; valorar el efecto de la adm\u00f3n de 3 formas de sm (sb-beta-cdx, sm z y sb base) sobre el estatus oxidativo tisular en un modelo de colestasis experimental.  &#8211; correlacionar el efecto sobre el estatus oxidativo tisular con la funci\u00f3n hep\u00e1tica y renal afectadas en la colestasis.  utilizamos como animal de experimentaci\u00f3n ratas macho de la cepa wistar, con un peso al principio del ensayo entre 300 y 350 gramos, mantenidas en todo momento en condiciones est\u00e1ndar de laboratorio.  se dise\u00f1aron 2 grupos experimentales:  . Animales sometidos a cirug\u00eda placebo (cp)  . Animales sometidos a un modelo de obstrucci\u00f3n biliar extrahep\u00e1tica mediante ligadura de col\u00e9d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto de silimarina sobre el estatus oxidativo en un modelo experimental de colestasis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto de silimarina sobre el estatus oxidativo en un modelo experimental de colestasis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gordillo Montoya Jos\u00e9 Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez Correa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis San rom\u00e1n del barrio <\/li>\n<li>m isabel Lucena gonzalez (vocal)<\/li>\n<li>m Luisa Martin  calvo (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gordillo Montoya Jos\u00e9 Manuel Las enfermedades hep\u00e1ticas representan un conjunto de patolog\u00edas muy importante y de gran 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