{"id":40231,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-interaccion-de-tocoferoles-y-lipopeptidos-anfipaticos-con-membranas-fosfolipidicas\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-de-la-interaccion-de-tocoferoles-y-lipopeptidos-anfipaticos-con-membranas-fosfolipidicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-la-interaccion-de-tocoferoles-y-lipopeptidos-anfipaticos-con-membranas-fosfolipidicas\/","title":{"rendered":"Estudio de la interaccion de tocoferoles y lipopeptidos anfipaticos con membranas fosfolipidicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alicia Grau Bonete <\/strong><\/h2>\n<p>En esta tesis doctoral se ha estudiado fundamentalmente la interacci\u00f3n de distintas mol\u00e9culas de gran inter\u00e9s biol\u00f3gico con membranas modelo. En la primera parte del trabajo se utiliz\u00f3 la fosfolipasa a2, como herramienta para comprobar el efecto estabilizador y desestabilizador de la incorporaci\u00f3n de diferentes is\u00f3meros del tocoferol, en membranas fosfolip\u00eddicas. los resultados mostraron una inhibici\u00f3n de tipo no competitivo \u00fanicamente en ves\u00edculas en estado lamelar fluido de la actividad pla2, por diferentes is\u00f3meros del tocoferol siguen un orden alfa&gt;beta&gt;gamma&gt;delta-tocoferol, correlacion\u00e1ndose este orden decreciente en cuanto al grado de inhibici\u00f3n de los is\u00f3meros bajo estudio con su actividad biol\u00f3gica como estabilizadores de membrana, sugiriendo otras posibles actividades biol\u00f3gicas de los compuestos con actividad vitamina e, aparte de su cl\u00e1sica funci\u00f3n como antioxidantes.  el estudio, en la segunda parte del trabajo, de la interacci\u00f3n de los lipop\u00e9ptidos surfactina e iturina a con membranas fosfolip\u00eddicas modelo, nos muestra para el caso de la surfactina, una interacci\u00f3n \u00f3ptima en el caso de fosfol\u00edpidos que poseen cadenas ac\u00edlicas de \u00e1cido mir\u00edstico, indicando el establecimiento de interacciones moleculares entre las cadenas ac\u00edlicas de los fosfol\u00edpidos y la mol\u00e9cula de surfactina, perturbando el comportamiento cooperativo de los l\u00edpidos. la mol\u00e9cula de surfactina se situar\u00eda en la parte superior de la empalizada lip\u00eddica, estableciendo interacciones con el agua y las cabezas polares de los l\u00edpidos. Esto podr\u00eda producir un aumento de las fuerzas repulsivas entre las bicapas adyacentes y en consecuencia un aumento del grosor de la bicapa.  los estudios de mezclas de surfactina con depe en fase hexagonal-hii mediante dsc, mostraron una destabilizaci\u00f3n de la fase hexagonal-hii, y en consecuencia una estabilizaci\u00f3n de la fase lamelar. Para el caso de iturina a, se produjo un e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la interaccion de tocoferoles y lipopeptidos anfipaticos con membranas fosfolipidicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la interaccion de tocoferoles y lipopeptidos anfipaticos con membranas fosfolipidicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alicia Grau Bonete <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Gomez Fernandez Juan  Carmelo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Gonzalez ros <\/li>\n<li>Mar\u00eda  Jes\u00fas Lopez zabalza (vocal)<\/li>\n<li>cristina Casals carro (vocal)<\/li>\n<li>Francisco Jos\u00e9 Aranda Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alicia Grau Bonete En esta tesis doctoral se ha estudiado fundamentalmente la interacci\u00f3n de distintas mol\u00e9culas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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