{"id":40237,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-las-caracteristicas-farmacocineticas-y-evaluacion-de-residuos-en-leche-de-endectocidas-moxidectina-y-doramectina-en-la-especie-caprina\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"determinacion-de-las-caracteristicas-farmacocineticas-y-evaluacion-de-residuos-en-leche-de-endectocidas-moxidectina-y-doramectina-en-la-especie-caprina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/determinacion-de-las-caracteristicas-farmacocineticas-y-evaluacion-de-residuos-en-leche-de-endectocidas-moxidectina-y-doramectina-en-la-especie-caprina\/","title":{"rendered":"Determinacion de las caracteristicas farmacocineticas y evaluacion de residuos en leche de endectocidas (moxidectina y doramectina) en la especie caprina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Sacramento Diaz Carrasco <\/strong><\/h2>\n<p>Se ha estudiado el comportamiento cin\u00e9tico de la moxidectina administrada por v\u00eda oral y subcut\u00e1nea en la cabra, a dosis de 0,2 mg\/kg, as\u00ed como de la doramectina administrada por v\u00eda subcut\u00e1nea a la misma dosis. El objetivo ha sido establecer los par\u00e1metros farmacocin\u00e9ticos de ambos f\u00e1rmacos en la especie caprina, por las v\u00edas estudiadas, comparando los perfiles farmacocin\u00e9ticos de dichos endectocidas, as\u00ed como discutir la idoneidad de su uso en funci\u00f3n de los mismos. As\u00ed mismo, se ha estudiado la eliminaci\u00f3n de moxidectina y doramectina en leche, para evaluar la importancia de los residuos. La determinaci\u00f3n de ambos productos, en plasma y leche, se realiz\u00f3 por cromatograf\u00eda l\u00edquida de alta presi\u00f3n (de montigny y col., 1990; alvinerie y col.,1995). El ajuste farmacocin\u00e9tico se realiz\u00f3 con los programas pkcalc (schumaker, 1986) y multi (yamaoka y col., 1986), consider\u00e1ndose el criterio de informaci\u00f3n de akaike (aic) el par\u00e1metro determinante para elegir el modelo farmacocin\u00e9tico m\u00e1s adecuado (yamaoka y col., 1978).  la moxidectina administrada tanto por v\u00eda subcut\u00e1nea como oral, se distribuye seg\u00fan un modelo bicompartimental, mientras que la cin\u00e9tica plasm\u00e1tica de la doramectina administrada por v\u00eda subcut\u00e1nea, se ajusta mejor a un modelo monocompartimental.  la moxidectina administrada por v\u00eda subcut\u00e1nea origina mayor auc y cmax que tras la administraci\u00f3n oral, mientras que los par\u00e1metros de velocidad de absorci\u00f3n y eliminaci\u00f3n no presentan diferencias significativas. Se elimina en una elevada proporci\u00f3n en leche, siendo la relaci\u00f3n de aucs entre leche y plasma del orden de 7,7, por ambas v\u00edas de administraci\u00f3n.  la doramectina administrada por v\u00eda subcut\u00e1nea presenta un perfil farmacocin\u00e9tico muy distinto al de la moxidectina administrada por la misma v\u00eda. Tanto el auc como el pico plasm\u00e1tico son inferiores para la doramectina; tambi\u00e9n es inferior la vida media de eliminaci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinacion de las caracteristicas farmacocineticas y evaluacion de residuos en leche de endectocidas (moxidectina y doramectina) en la especie caprina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinacion de las caracteristicas farmacocineticas y evaluacion de residuos en leche de endectocidas (moxidectina y doramectina) en la especie caprina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Sacramento Diaz Carrasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elisa Escudero Pastor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: arturo Brugger auban <\/li>\n<li> Alonso de vega Francisco (vocal)<\/li>\n<li>Miguel angel Bregante ucedo (vocal)<\/li>\n<li> Ponferrada abrisqueta Carlos Javier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Sacramento Diaz Carrasco Se ha estudiado el comportamiento cin\u00e9tico de la moxidectina administrada por v\u00eda oral [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,515,5675,8235,1944,1946,17,457],"tags":[59452,8311,41552,102885,5679,102886],"class_list":["post-40237","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-veterinarias","category-farmacologia-veterinaria","category-murcia","category-ovinos","category-produccion-animal","category-quimica","category-quimica-farmaceutica","tag-alonso-de-vega-francisco","tag-arturo-brugger-auban","tag-elisa-escudero-pastor","tag-m-sacramento-diaz-carrasco","tag-miguel-angel-bregante-ucedo","tag-ponferrada-abrisqueta-carlos-javier"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40237"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40237\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}