{"id":40288,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/lesion-plaquetaria-de-almacenamiento-degradacion-del-complejo-glicoproteico-ib-ix-v-y-utilidad-de-inhibidores-de-la-activacion-plaquetaria-en-su-prevencion\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"lesion-plaquetaria-de-almacenamiento-degradacion-del-complejo-glicoproteico-ib-ix-v-y-utilidad-de-inhibidores-de-la-activacion-plaquetaria-en-su-prevencion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/lesion-plaquetaria-de-almacenamiento-degradacion-del-complejo-glicoproteico-ib-ix-v-y-utilidad-de-inhibidores-de-la-activacion-plaquetaria-en-su-prevencion\/","title":{"rendered":"Lesion plaquetaria de almacenamiento: degradacion del complejo glicoproteico ib\/ix\/v y utilidad de inhibidores de la activacion plaquetaria en su prevencion."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Luisa Lozano Almela <\/strong><\/h2>\n<p>Los objetivos de esta memoria fueron, en primer lugar, analizar si durante el almacenamiento de concentrados de plaquetas (cps) se produce una p\u00e9rdida de la reactividad de las c\u00e9lulas a la trombina, y la posible relaci\u00f3n con la disminuci\u00f3n de sitios de alta afinidad para el agonista localizados en el complejo glicoproteico ib\/ix\/v. En segundo lugar, se valor\u00f3 la utilidad de diversos agentes en la prevenci\u00f3n del da\u00f1o plaquetario por almacenamiento: (1) sustancias moduladoras del ampc (pge1, forscolina, teofilina e isobutil-metilxantina  ibmx  ), y aniones org\u00e1nicos (piruvato y acetato s\u00f3dicos) en la conservaci\u00f3n a 22 grados c; (2) thrombosol (combinaci\u00f3n de los efectores de segundos mensajeros adenosina, nitroprusiato s\u00f3dico, dipiridamol, ticlopidina, quinacrina y amiloride) en el almacenamiento a 4 grados c; (3) soluci\u00f3n modificada de thrombosol (nitroprusiato s\u00f3dico, dipiridamol y amiloride) y dimetilsulf\u00f3xido   dmso  al 2%, en la criopreservaci\u00f3n de las c\u00e9lulas.  para ello se utiliz\u00f3 metodolog\u00eda est\u00e1ndar de laboratorios de hematolog\u00eda y bioqu\u00edmica en el an\u00e1lisis de recuentos celulares, vol\u00famenes plaquetarios medios, ph, concentraciones de di\u00f3xido de carbono, ox\u00edgeno, bicarbonato, glucosa y lactato deshidrogenasa. Los niveles de lactato se valoraron mediante an\u00e1lisis enzim\u00e1ticos, y las de tromboxano b2 y ampc con inmunoensayos. La expresi\u00f3n en superficie plaquetaria de glicoprote\u00ednas (gp) se evalu\u00f3 con citometr\u00eda de flujo. la uni\u00f3n de trombina y de ligandos (factor von willebrand y fibrin\u00f3geno) a las plaquetas se estudi\u00f3 con an\u00e1lisis de uni\u00f3n en \u00abfr\u00edo\u00bb y \u00abcaliente\u00bb, respectivamente.  de los estudios realizados en este trabajo, se obtuvieron los siguientes resultados\/conclusiones:  1. A lo largo del almacenamiento est\u00e1ndar de cps se produjo una progresiva disminuci\u00f3n de las respuestas de las c\u00e9lulas a la trombina. Durante dicho periodo se observ\u00f3 una reducci\u00f3n en la expresi\u00f3n superfi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Lesion plaquetaria de almacenamiento: degradacion del complejo glicoproteico ib\/ix\/v y utilidad de inhibidores de la activacion plaquetaria en su prevencion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Lesion plaquetaria de almacenamiento: degradacion del complejo glicoproteico ib\/ix\/v y utilidad de inhibidores de la activacion plaquetaria en su prevencion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Luisa Lozano Almela <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Vicente Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Ballesta german <\/li>\n<li>Javier Battle fonrodona (vocal)<\/li>\n<li>Fernando Hern\u00e1ndez navarro (vocal)<\/li>\n<li>tomas Quesada perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Luisa Lozano Almela Los objetivos de esta memoria fueron, en primer lugar, analizar si durante el 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