{"id":40350,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/amplificacion-de-la-region-11q13-en-los-carcinomas-epidermoides-de-cabeza-y-cuello\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"amplificacion-de-la-region-11q13-en-los-carcinomas-epidermoides-de-cabeza-y-cuello","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/amplificacion-de-la-region-11q13-en-los-carcinomas-epidermoides-de-cabeza-y-cuello\/","title":{"rendered":"Amplificacion de la region 11q13 en los carcinomas epidermoides de cabeza y cuello."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Gonzalez Luis Amando <\/strong><\/h2>\n<p>La amplificaci\u00f3n de 11q13 ha sido hallada frecuentemente en carcinomas epidermoides de cabeza y cuello indicando mal pron\u00f3stico. La amplificaci\u00f3n de int2 y hst1 ha sido detectada con frecuencia, sin embargo no se sobreexpresa en los tumores. Los genes prad1 y ems1 han sido identificados como oncogenes \u00abactivos\u00bb en esta regi\u00f3n, puesto que se encuentran sobreexpresados en los carcinomas.  el objetivo de esta investigaci\u00f3n es estudiar la amplificaci\u00f3n de 11q13 en carcinomas de cabeza y cuello y evaluar su correlaci\u00f3n con las variables cl\u00ednico-patol\u00f3gicas, evoluci\u00f3n y supervivencia.  muestras de tejido tumoral de 104 pacientes con carcinomas epidermoides de cabeza y cuello fueron analizadas. El n\u00famero de copias de los oncogenes de 11q13 fue estudiado utilizando el m\u00e9todo de la reacci\u00f3n en cadena de polimerasa (pcr). La presencia o ausencia de amplificaci\u00f3n se correlacion\u00f3 con la localizaci\u00f3n, par\u00e1metros cl\u00ednico-patol\u00f3gicos, evoluci\u00f3n y supervivencia. La amplificaci\u00f3n de int2\/hst1 se correlacion\u00f3 con la localizaci\u00f3n en hipofaringe, estadios t avanzados y la afectaci\u00f3n ganglionar. la amplificaci\u00f3n de prad1 se correlacion\u00f3 con estadios n+, y mostr\u00f3 tendencia a estar asociado a tumores de hipofaringe y recidiva del tumor. La amplificaci\u00f3n de ems1 ems1 se relacion\u00f3 con estadios t avanzados, afectaci\u00f3n de n\u00f3dulos linf\u00e1ticos y pobre diferenciaci\u00f3n histol\u00f3gica. La amplificaci\u00f3n de ems1 tuvo un efecto significativo sobre la supervivencia. El an\u00e1lisis multivariante, hall\u00f3 la amplificaci\u00f3n de ems1 como un factor pron\u00f3stico independiente sobre la mortalidad por el tumor.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Amplificacion de la region 11q13 en los carcinomas epidermoides de cabeza y cuello.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Amplificacion de la region 11q13 en los carcinomas epidermoides de cabeza y cuello. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Gonzalez Luis Amando <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Suarez Nieto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Sanchez lazo <\/li>\n<li>Javier Gavil\u00e1n bouzas (vocal)<\/li>\n<li>Carlos Lopez otin (vocal)<\/li>\n<li>Francisco Esteban ortega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Gonzalez Luis Amando La amplificaci\u00f3n de 11q13 ha sido hallada frecuentemente en carcinomas epidermoides de cabeza [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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