{"id":40360,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-implicados-en-el-inotropismo-positivo-inducido-por-androgenos-en-auricula-aislada-de-rata\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"mecanismos-implicados-en-el-inotropismo-positivo-inducido-por-androgenos-en-auricula-aislada-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-implicados-en-el-inotropismo-positivo-inducido-por-androgenos-en-auricula-aislada-de-rata\/","title":{"rendered":"Mecanismos implicados en el inotropismo positivo inducido por androgenos en auricula aislada de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Manuel Rubin Lopez <\/strong><\/h2>\n<p>Los andr\u00f3genos producen cambios fisiol\u00f3gicos en el coraz\u00f3n. As\u00ed, es conocida la diferencia en el fenotipo cardiaco y los efectos electrofisiol\u00f3gicos, como el acortamiento del intervalo qt, tras la pubertad en varones. Stos son debidos a la activaci\u00f3n de receptores intracelulares. Sin embargo, interacciones de andr\u00f3genos con la membrana plasm\u00e1tica pueden dar lugar a efectos r\u00e1pidos independientes de mecanismos gen\u00f3micos. En este sentido, los andr\u00f3genos producen efectos hemodin\u00e1micos de r\u00e1pida instauraci\u00f3n por reducir el tono de los vasos coronarios y la aorta. A su vez, en nuestro laboratorio se ha descrito que la 5alfa- y 5beta-dihidrotestosterona producen un r\u00e1pido inotropismo positivo en la aur\u00edcula izquierda aislada de rata, estimulada el\u00e9ctricamente. Sin embargo, no se han descartado posibles mecanismos gen\u00f3micos en dicha respuesta. La s\u00edntesis de poliaminas y el aumento de ampc intracelular, tambi\u00e9n se han relacionado con efectos no gen\u00f3micos de los andr\u00f3genos. En este presente trabajo, se ha estudiado la posible naturaleza gen\u00f3mica y la participaci\u00f3n de mecanismos dependientes de ampc y poliaminas en dicho efecto.  los resultados muestran la existencia de mecanismos transcripcionales y s\u00edntesis proteica en dicho efecto, ya que se inhibe por la incubaci\u00f3n de las preparaciones con actinomicina d y cicloheximida. farmacol\u00f3gicamente, hemos puesto de manifiesto que es producido postsin\u00e1pticamente por mecanismos dependientes de ampc y por interacci\u00f3n a nivel de la membrana plasm\u00e1tica, ya que se inhibe por un inhibidor de la adenilato ciclasa, dideoxiadenosina, un inhibidor de la prote\u00edna kinasa a, rp-camps, y tras la incubaci\u00f3n con toxina pertussis, inhibidor de prote\u00ednas g sensibles. El atenolol, un bloqueante de los receptores beta-adren\u00e9rgicos tambi\u00e9n antagoniz\u00f3 el efecto cardiot\u00f3nico de los andr\u00f3genos. Por tanto, se requiere la integridad funcional de los receptores beta-adren\u00e9rgicos. a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos implicados en el inotropismo positivo inducido por androgenos en auricula aislada de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos implicados en el inotropismo positivo inducido por androgenos en auricula aislada de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Manuel Rubin Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Sanchez Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Andres rodriguez-trelles Fernando de <\/li>\n<li>Antonio Fueyo silva (vocal)<\/li>\n<li>arturo Cortina llosa (vocal)<\/li>\n<li>Jes\u00fas Llenas clavo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Manuel Rubin Lopez Los andr\u00f3genos producen cambios fisiol\u00f3gicos en el coraz\u00f3n. As\u00ed, es conocida la diferencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,6530,8846],"tags":[7122,60435,2975,103068,58664,9019],"class_list":["post-40360","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacologia-experimental","category-oviedo","tag-andres-rodriguez-trelles-fernando-de","tag-antonio-fueyo-silva","tag-arturo-cortina-llosa","tag-jesus-llenas-clavo","tag-jose-manuel-rubin-lopez","tag-manuel-sanchez-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40360"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40360\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}