{"id":40361,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-y-significacion-clinica-de-la-proteina-p53-e-cadherina-cd44-y-pepsinogeno-c-en-el-cancer-de-pancreas\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"expresion-y-significacion-clinica-de-la-proteina-p53-e-cadherina-cd44-y-pepsinogeno-c-en-el-cancer-de-pancreas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-y-significacion-clinica-de-la-proteina-p53-e-cadherina-cd44-y-pepsinogeno-c-en-el-cancer-de-pancreas\/","title":{"rendered":"Expresion y significacion clinica de la proteina p53, e-cadherina, cd44 y pepsinogeno c en el cancer de pancreas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nuria Truan Alonso <\/strong><\/h2>\n<p>Introduccin: la incidencia del c\u00e1ncer de p\u00e1ncreas ha ido aumentando progresivamente en los \u00faltimos a\u00f1os. El comportamiento biol\u00f3gico de este tumor es muy agresivo, con una supervivencia tras cirug\u00eda de ex\u00e9resis, que no supera el 20% a los 5 a\u00f1os.  hiptesis y objetivos: la p\u00e9rdida de funci\u00f3n supresora de proliferaci\u00f3n celular, la alteraci\u00f3n en las propiedades adhesivas de las c\u00e9lulas y la facilidad para degradar la matriz extracelular son factores que te\u00f3ricamente favorecen el crecimiento y la progresi\u00f3n tumoral, por lo que su concurrencia en el c\u00e1ncer pancre\u00e1tico podr\u00eda condicionar su agresividad. Los objetivos son analizar la expresi\u00f3n de la oncoprote\u00edna p53, las mol\u00e9culas de adhesi\u00f3n e-cadherina y cd44s, y el precursor enzim\u00e1tico pepsin\u00f3geno c en el adenocarcinoma pancre\u00e1tico, y correlacionar dicha expresi\u00f3n con caracter\u00edsticas cl\u00ednicas e histol\u00f3gicas del tumor, as\u00ed como estudiar su posible valor pron\u00f3stico.  material y mtodos: se realiza una valoraci\u00f3n de la expresi\u00f3n de prote\u00edna p53, e-cadherina, cd44 y pepsin\u00f3geno c mediante t\u00e9cnica inmunohistoqu\u00edmica sobre 86 casos de adenocarcinoma ductal panere\u00e1tico intervenidos con intenci\u00f3n curativa. Se realiza tambi\u00e9n un seguimiento de los pacientes para analizar la supervivencia, excluyendo de este an\u00e1lisis la mortalidad postoperatoria.  resultados y conclusiones: hemos encontrado un 34,9% de inmunopositividad para p53 a nivel nuclear, 41,9% para cd44 a nivel de membrana y un 27,9% para pepsin\u00f3geno c a nivel citoplasm\u00e1tico. Adem\u00e1s hemos constatado que el 40,7% de los tumores han perdido la capacidad de expresar en su membrana la mol\u00e9cula de adhesi\u00f3n e-cadherinas, una de las mol\u00e9culas m\u00e1s importantes para mantener la adhesi\u00f3n celular. El alto porcentaje de expresi\u00f3n de la oncoprote\u00edna p53 probablemente implica que la mutaci\u00f3n del gen tp53 es un acontecimiento que interviene en la tumorog\u00e9nesis de un considerable porcentaje de los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion y significacion clinica de la proteina p53, e-cadherina, cd44 y pepsinogeno c en el cancer de pancreas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion y significacion clinica de la proteina p53, e-cadherina, cd44 y pepsinogeno c en el cancer de pancreas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nuria Truan Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fresno Forcelledo Manuel Florentino<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  sebastian Lopez arranz arranz <\/li>\n<li>Jos\u00e9 Fernando Val bernal (vocal)<\/li>\n<li>Jes\u00fas \u00e1lvarez fern\u00e1ndez-represa (vocal)<\/li>\n<li> Diego carmona Miguel angel de (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nuria Truan Alonso Introduccin: la incidencia del c\u00e1ncer de p\u00e1ncreas ha ido aumentando progresivamente en los \u00faltimos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,1027,8846,156],"tags":[103070,50374,2338,10583,37900,103069],"class_list":["post-40361","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-oncologia","category-oviedo","category-patologia","tag-diego-carmona-miguel-angel-de","tag-fresno-forcelledo-manuel-florentino","tag-jesus-alvarez-fernandez-represa","tag-jose-fernando-val-bernal","tag-juan-sebastian-lopez-arranz-arranz","tag-nuria-truan-alonso"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40361"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40361\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}