{"id":40404,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/biosintesis-de-mitramicina-por-streptomyces-argillaceus-caracterizacion-de-genes-implicados-en-la-modificacion-de-la-estructura-policetidica\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"biosintesis-de-mitramicina-por-streptomyces-argillaceus-caracterizacion-de-genes-implicados-en-la-modificacion-de-la-estructura-policetidica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/biosintesis-de-mitramicina-por-streptomyces-argillaceus-caracterizacion-de-genes-implicados-en-la-modificacion-de-la-estructura-policetidica\/","title":{"rendered":"Biosintesis de mitramicina por streptomyces argillaceus: caracterizacion de genes implicados en la modificacion de la estructura policetidica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Prado Alvarez <\/strong><\/h2>\n<p>Se han secuenciado tres regiones pertenecientes al adn cromos\u00f3mico de streptomyces argillaceus atcc 12596 revelando la existencia de ocho pautas de lectura abierta completas: mtml,mtmoiii, mtmoii,mtmtii,mtmti,mtmoi,mtmy,mtmtiii, mtmoiv. Mtml podr\u00eda ser una acetil coa ligasa.Mtmy podr\u00eda ser una ciclasa implicada en la ciclaci\u00f3n del 2 y 3 anillo de la mitramicina.Mtmti,mtmtii y mtmtiii podr\u00edan ser reductasas implicadas en distintos pasos de la ruta de biosintesis de mitramicina.Mtmoiii podr\u00eda ser una semiquinona monooxigenasa, que no parece esencial para la biosintesis de mitramicina, ya que al inactivar el gen la codifica el mutante sigue produciendo mitramicina.Mtmoi,mtmoii y mtmoiv parecen ser oxigenasas tipo flav\u00edn. Mediante su inactivaci\u00f3n se ha comprobado que mtmoi no es esencial, mtmoii podr\u00eda introducir dos grupos hidroxilos y mtmoiv hidroxila el c-3 de la mitramicina provocando la ruptura del 4 anillo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Biosintesis de mitramicina por streptomyces argillaceus: caracterizacion de genes implicados en la modificacion de la estructura policetidica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Biosintesis de mitramicina por streptomyces argillaceus: caracterizacion de genes implicados en la modificacion de la estructura policetidica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Prado Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Del Carmen M\u00e9ndez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  evaristo Suarez fernandez <\/li>\n<li>ram\u00f3n Santamar\u00eda s\u00e1nchez (vocal)<\/li>\n<li>Mar\u00eda enriqueta Arias fern\u00e1ndez (vocal)<\/li>\n<li>Francisco Malpartida romero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Prado Alvarez Se han secuenciado tres regiones pertenecientes al adn cromos\u00f3mico de streptomyces argillaceus atcc 12596 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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