{"id":40462,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-digoxina-acenocumarol-implicaciones-terapeuticas\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"interaccion-digoxina-acenocumarol-implicaciones-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/interaccion-digoxina-acenocumarol-implicaciones-terapeuticas\/","title":{"rendered":"Interaccion digoxina-acenocumarol: implicaciones terapeuticas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Drury Atencio <\/strong><\/h2>\n<p>Se han estudiado las modificaciones en la farmacocin\u00e9tica de digoxina en presencia de acenocumarol en animales de experimentaci\u00f3n. los resultados demuestran que el acenocumarol provoca una reducci\u00f3n de los niveles plasm\u00e1ticos de digoxina debida a incrementos en el volumen aparente de distirbuci\u00f3n. Esto fue corroborado por estudios \u00abin vitro\u00bb utilizando homogenados de coraz\u00f3n mediante la t\u00e9cnica de di\u00e1lisis de equilibrio. Para la determinaci\u00f3n de las concentraciones de digoxina de estas muestras se ha puesto a punto y validado una t\u00e9cnica por h.P.L.C.  se ha comprobado la existencia de la interacci\u00f3n en humanos utilizando datos de la monitorizaci\u00f3n de digoxina. Igualmente se encontraron reducciones en los niveles de digoxina en los pacientes sometidos a tratamiento con acenocumarol debidas a cambios en los procesos de eliminaci\u00f3n de digoxina pero sin descartar la posible influencia en la distribuci\u00f3n del f\u00e1rmaco..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interaccion digoxina-acenocumarol: implicaciones terapeuticas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interaccion digoxina-acenocumarol: implicaciones terapeuticas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Drury Atencio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Martinez Lanao<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Jes\u00fas Dominguez gil hurle <\/li>\n<li>anna cristina Calpena campmany (vocal)<\/li>\n<li>ignacio Alberca silva (vocal)<\/li>\n<li>Manuel Valera mackay (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Drury Atencio Se han estudiado las modificaciones en la farmacocin\u00e9tica de digoxina en presencia de acenocumarol en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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