{"id":40466,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevas-aportaciones-a-la-caracterizacion-molecular-y-farmacologica-del-receptor-opioide-kappa\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"nuevas-aportaciones-a-la-caracterizacion-molecular-y-farmacologica-del-receptor-opioide-kappa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevas-aportaciones-a-la-caracterizacion-molecular-y-farmacologica-del-receptor-opioide-kappa\/","title":{"rendered":"Nuevas aportaciones a la caracterizacion molecular y farmacologica del receptor opioide kappa."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Malvar Gutierrez Francisco Jose <\/strong><\/h2>\n<p>Los opioides y opi\u00e1ceos ejercen acciones inmunoreguladoras sobre las c\u00e9lulas del sistema inmune a trav\u00e9s de receptores opioides hipotal\u00e1micos y de receptores opioides presentes en las propias c\u00e9lulas del sistema inmune. El receptor opioide kappa parece expresarse en c\u00e9lulas t. En este trabajo, mediante estudios de rt-pcr, escrutinio de genotecas, m\u00e9todo de southern y estudios de uni\u00f3n de ligandos y de su eficacia sobre el receptor opioide kappa, se demuestra la presencia de receptores opioides kappa, hom\u00f3logos a los presentes en el sistema nervioso central, en c\u00e9lulas, t cd4+ y en la l\u00ednea celular de timoma, precursora del c\u00e9lulas t, riego.  mediante los estudios moleculares se pone de manifiesto la existencia de dos transcritos de procesamiento alternativo del gen del receptor opioide kappa humano, as\u00ed como la presencia de una secuencia repetitiva alu en el intr\u00f3n 3 del gen que codifica para este receptor; esta secuencia podr\u00eda estar implicada en la aparici\u00f3n de polimorfismos del receptor.  mediante estudios de uni\u00f3n al receptor de ligandos y de su eficacia sobre el receptor opioide, se ha podido evidenciar la existencia de lugares de uni\u00f3n kappa-1 y kappa-2 en la superficie de estas c\u00e9lulas riego de origen inmunol\u00f3gico. Sobre este modelo experimental el ligando opioide diprenorfina se comporta como un agonista parcial y no como un antagonista, como se consideraba hasta el momento.  la exposici\u00f3n cr\u00f3nica a agonistas opi\u00e1ceos sobre estas c\u00e9lulas provoca una disminuci\u00f3n del n\u00famero de receptores presentes en las mismas, debido a la activaci\u00f3n prolongada del receptor; este efecto se considera una de las bases de la tolerancia a opi\u00e1ceos, y, comprobar que tambi\u00e9n se da sobre c\u00e9lulas de origen inmunol\u00f3gico, supone otro hallazgo importante..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevas aportaciones a la caracterizacion molecular y farmacologica del receptor opioide kappa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevas aportaciones a la caracterizacion molecular y farmacologica del receptor opioide kappa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Malvar Gutierrez Francisco Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raquel Emilia Rodr\u00edguez Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: m. paz Battaner arias <\/li>\n<li>gregorio Valencia parrera (vocal)<\/li>\n<li>Miguel Cordero sanchez (vocal)<\/li>\n<li>victoria Nilanes Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Malvar Gutierrez Francisco Jose Los opioides y opi\u00e1ceos ejercen acciones inmunoreguladoras sobre las c\u00e9lulas del sistema [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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