{"id":40469,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-de-47a-dimetilhidroindenos-15-disustituidos-actividad-inotropica-e-inhibicion-de-atpasa-nak\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"sintesis-de-47a-dimetilhidroindenos-15-disustituidos-actividad-inotropica-e-inhibicion-de-atpasa-nak","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sintesis-de-47a-dimetilhidroindenos-15-disustituidos-actividad-inotropica-e-inhibicion-de-atpasa-nak\/","title":{"rendered":"Sintesis de 4,7a-dimetilhidroindenos 1,5-disustituidos. actividad inotropica e inhibicion de atpasa-na+,k+."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00aa. Concepci\u00f3n P\u00e9rez Melero <\/strong><\/h2>\n<p>Este trabajo de tesis doctoral se encuadra dentro de una l\u00ednea de investigaci\u00f3n que se desarrolla en el departamento de qu\u00edmica farmac\u00e9utica de esta universidad sobre an\u00e1logos simplificados de cardenolidas, compuestos utilizados en el tratamiento de la insuficiencia cardiaca.  se han sintetizado distintos derivados con estructura de 4,7a-hidroindeno, diferentemente sustituidos en las posiciones c1 y c5, pertenecientes a dos grupos: perhidroindenos o hidroindenos insaturados en posici\u00f3n c3a.  ha sido puesta a punto la metodolog\u00eda adecuada para la obtenci\u00f3n del material de partida, el 4alfa-metil derivado de la dicetona de hajos-parrish, mediante la utilizaci\u00f3n de s-(-)prolina como inductor quiral y adici\u00f3n al medio de reacci\u00f3n de piperidina en peque\u00f1as cantidades a intervalos de 1,5 h.  a partir de dicho compuesto, se ha estabelcido una ruta sint\u00e9tica para la preparaci\u00f3n de diversos productos finales, siendo intermedio clave en dicha ruta el acetal etil\u00e9nico de (1s, 3as, 4s, 7ar)-1-formil -3a-hidroxi-4,7a-dimetilperhidroinden-5-ona. los productos finales se encuentran diferentemente sustituidos en posiciones c1 (hidroximetil, aldeh\u00eddo, \u00e1cido carbox\u00edlico, cadenas alda,beta-insaturadas, guanilhidrazonas) y c5 (carbonilo, hidroxilo, cadenas lineales, restos c\u00edclicos). Se ha llevado a cabo asimismo el an\u00e1lisis conformacional de estos derivados.  se ha evaluado la capacidad de estos an\u00e1logos como agentes inotr\u00f3picos positivos y como inhibidores de la enzima atpasa-na+,k+, obteni\u00e9ndose los mejores resultados con la bis(guanilhidrazona) de (1s, 7ar)-4,7a-dimetil- 5-oxo-8,3,5,6,7,7a-hexahidro-1h-indeno-1-carbaldeh\u00eddo, que produce un aumento de la fuerza de contracci\u00f3n en aur\u00edcula de cobaya de hasta un 200% sin afectar a la frecuencia cardiaca, y adem\u00e1s inhibe la atpasa-na+,k+, diferenciando entre las isoenzimas de la misma..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis de 4,7a-dimetilhidroindenos 1,5-disustituidos. actividad inotropica e inhibicion de atpasa-na+,k+.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis de 4,7a-dimetilhidroindenos 1,5-disustituidos. actividad inotropica e inhibicion de atpasa-na+,k+. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00aa. Concepci\u00f3n P\u00e9rez Melero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo San Feliciano Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis San rom\u00e1n del barrio <\/li>\n<li>vicente Gotor santamar\u00eda (vocal)<\/li>\n<li>Juan Galbis perez (vocal)<\/li>\n<li>Mar\u00eda  lLuisa Bennasar felix (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00aa. Concepci\u00f3n P\u00e9rez Melero Este trabajo de tesis doctoral se encuadra dentro de una l\u00ednea de investigaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,17670,957,17,457,416,9386],"tags":[3425,3212,7196,55106,103240,6659],"class_list":["post-40469","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-diseno-sintesis-y-estudio-de-nuevos-farmacos","category-farmacologia","category-quimica","category-quimica-farmaceutica","category-quimica-organica","category-salamanca","tag-arturo-san-feliciano-martin","tag-juan-galbis-perez","tag-luis-san-roman-del-barrio","tag-maria-lluisa-bennasar-felix","tag-ma-concepcion-perez-melero","tag-vicente-gotor-santamaria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40469"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40469\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}