{"id":40523,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/localizacion-de-neurotrofinas-y-sus-receptores-en-el-sistema-visual-efecto-de-la-regeneracion-del-nervio-optico-de-la-tenca\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"localizacion-de-neurotrofinas-y-sus-receptores-en-el-sistema-visual-efecto-de-la-regeneracion-del-nervio-optico-de-la-tenca","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/localizacion-de-neurotrofinas-y-sus-receptores-en-el-sistema-visual-efecto-de-la-regeneracion-del-nervio-optico-de-la-tenca\/","title":{"rendered":"Localizacion de neurotrofinas y sus receptores en el sistema visual: efecto de la regeneracion del nervio optico de la tenca."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Elena Caminos Benito <\/strong><\/h2>\n<p>Las neurotrofinas y sus receptores est\u00e1n implicados en la supervivencia, diferenciaci\u00f3n y desarrollo de las neuronas. para entender el papel de estas mol\u00e9culas en el sistema visual, hemos investigado su distribuci\u00f3n en la retina, nervio \u00f3ptico, techo \u00f3ptico y n\u00facleos pre\u00f3pticos de un tele\u00f3steo (la tenca), que tiene capacidad de regenerar su sistema nervioso despu\u00e9s de una lesi\u00f3n, y en la retina de un mam\u00edfero (la rata), que carece de dicha capacidad.  para desarrollar este trabajo, realizamos el pinzamiento del nervio \u00f3ptico de tencas que despu\u00e9s permanecieron vivas entre 1 y 250 d\u00edas. Empleamos t\u00e9cnicas inmunohistoqu\u00edmicas (anticuerpos contra ngf, bdnf, nt-3, nt-4\/5, trka, trkb, trkc y p75); histoqu\u00edmica; hibridaci\u00f3n in situ, inmunoprecipitaci\u00f3n y western blot.  detectamos: ngf y bdnf en c\u00e9lulas de muller en tecna; el mrna de bdnf y trkb en retinas de ratas adultas y neonatales; bdnf, nt-3, trka y trkb en macrogl\u00eda del nervio \u00f3ptico normal. Entre 4 y 90 d\u00edas despu\u00e9s de la lesi\u00f3n, la inmunorreactividad de trka y su mrna aumentaron en la retina de tenca y todas las neurotrofinas, excepto nt-3, y sus receptores los detectados en macr\u00f3fagos del nervio \u00f3ptico. Entre 15 y 30 d\u00edas despu\u00e9s de la lesi\u00f3n observamos terminaciones bdmf-inmunorreactivas s\u00f3lo en el hemitecho cotralateral al nervio lesionado.  estos resultados nos indican que ciertas neurotrofinas actuan en la retina de tenca a trav\u00e9s de las cbelulas de muller, y en el nervio \u00f3ptico a trav\u00e9s de c\u00e9lulas macromicrogliales; que trka est\u00e1 implicado en los procesos de regeneraci\u00f3n de la retina de tenca; que bdnf y trkb intervienen en el desarrollo y funcionamiento normal de la retina de rata; y que bdnf participa en la reorganizaci\u00f3n y reestablecimiento de las sinapsis en el techo \u00f3ptico durante la regeneraci\u00f3n de los axones \u00f3pticos..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Localizacion de neurotrofinas y sus receptores en el sistema visual: efecto de la regeneracion del nervio optico de la tenca.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Localizacion de neurotrofinas y sus receptores en el sistema visual: efecto de la regeneracion del nervio optico de la tenca. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Elena Caminos Benito <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodriguez Perez M. Thereza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Mechan cifuentes <\/li>\n<li>Manuel Vidal sanz (vocal)<\/li>\n<li> Villegas perez Mar\u00eda  paz (vocal)<\/li>\n<li>Juan  Miguel Ar\u00e9chaga mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Elena Caminos Benito Las neurotrofinas y sus receptores est\u00e1n implicados en la supervivencia, diferenciaci\u00f3n y desarrollo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,35,848,1737,2612,4275,9386],"tags":[13203,103341,7462,103343,103342,102669],"class_list":["post-40523","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-de-la-vida","category-citologia","category-inmunologia","category-inmunoquimica","category-neurociencias","category-salamanca","tag-juan-miguel-arechaga-Martinez","tag-m-elena-caminos-benito","tag-manuel-vidal-sanz","tag-miguel-mechan-cifuentes","tag-rodriguez-perez-m-thereza","tag-villegas-perez-maria-paz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40523"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40523\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}