{"id":40527,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-peptido-glucagon-like-peptide-17-36amide-con-anticuerpos-poli-y-monoclonales\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-del-peptido-glucagon-like-peptide-17-36amide-con-anticuerpos-poli-y-monoclonales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-del-peptido-glucagon-like-peptide-17-36amide-con-anticuerpos-poli-y-monoclonales\/","title":{"rendered":"Estudio del peptido glucagon-like peptide-1(7-36)amide con anticuerpos poli- y monoclonales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jozef Van Delft <\/strong><\/h2>\n<p>El \u00abglucagon-like peptide-1\u00bb (glp-1) es uno de los productos del procesamiento postraduccional del proglucag\u00f3n. El p\u00e9ptido existe en diferentes formas moleculares, pero s\u00f3lo las formas glp-1(7-37) y glp-1(7-36)nh2 tienen actividad biol\u00f3gica, representando esta \u00faltima un 80% de la totalidad del glp-1 biol\u00f3gicamente activo.  esta tesis tuvo por objetivo el desarrollo de un radioinmunoensayo (ria) muy sensible para las formas amidadas de glp-1, el uso de este ria, en combinaci\u00f3n con hplc, para valorar la producci\u00f3n de glp-1(7-36)nh2 en el hipot\u00e1lamo, el p\u00e1ncreas y el \u00edleon en comparaci\u00f3n con la inmunorreactividad \u00abglucagon-like\u00bb (gli) y el glucag\u00f3n inmunorreactivo (irg) en estos tejidos y el bloqueo del p\u00e9ptido end\u00f3geno con anticuerpos monoclonales.  la inmunizaci\u00f3n de conejos con un conjugado de glp-1(7-36)nh2 con alb\u00famina bovina, obtenido mediante reacci\u00f3n con glutarldehido, permiti\u00f3 obtener un antisuero (cr14c) de t\u00edtulo elevado, alta afinidad y espec\u00edfico para el extremo c-terminal amidado del p\u00e9ptido. El ria desarrollado con cr14c era muy sensible y pudo ser utilizado para determinaciones de glp-1 amidado en extractos de tejido y muestras peque\u00f1as de plasma de rata.  la producci\u00f3n de glp-1(7-36)nh2 result\u00f3 muy eficaz en el hipot\u00e1lamo, lo cual indica el posible papel de esta forma molecular como neurop\u00e9ptido. en el p\u00e1ncreas, el glp-1(7-36)nh2 estuvo presente en cantidades muy peque\u00f1as, lo cual argumenta en contra de un papel para el glp-1(7-36)nh2 producido en el p\u00e1ncreas en la secrecci\u00f3n de insulina. En el ileon, la producci\u00f3n de glp-1(7-36)nh2 result\u00f3 muy variable, y fue menos eficaz que lo que se desprende de trabajos anteriores. En uno de los animales, se detect\u00f3 tambi\u00e9n glp-1(1-36)nh2 en cantidades apreciables.  el bloqueo de glp-1(7-36)nh2 en ratas wistar conscientes y en ayunas, por la administraci\u00f3n intraperitoneal de ant\u00edcuerpos monoclonales contra dos epitopos diferentes de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del peptido glucagon-like peptide-1(7-36)amide con anticuerpos poli- y monoclonales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del peptido glucagon-like peptide-1(7-36)amide con anticuerpos poli- y monoclonales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jozef Van Delft <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Margarita Ghiglione Juan es<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: m. paz Battaner arias <\/li>\n<li> Lopez rodriguez Mar\u00eda  a. (vocal)<\/li>\n<li>Jos\u00e9 Rodrigo garcia (vocal)<\/li>\n<li>Jos\u00e9 enrique Campillo \u00e1lvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jozef Van Delft El \u00abglucagon-like peptide-1\u00bb (glp-1) es uno de los productos del procesamiento postraduccional del proglucag\u00f3n. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,35,2135,817,969,17,9386],"tags":[1743,14594,103351,3904,19749,103352],"class_list":["post-40527","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-ciencias-de-la-vida","category-fisiologia-endocrina","category-fisiologia-humana","category-peptidos","category-quimica","category-salamanca","tag-jose-enrique-campillo-alvarez","tag-jose-rodrigo-garcia","tag-jozef-van-delft","tag-lopez-rodriguez-maria-a","tag-m-paz-battaner-arias","tag-margarita-ghiglione-juan-es"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40527","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40527"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40527\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40527"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}