{"id":40528,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-diferenciacion-en-la-expresion-de-la-sintasa-del-oxido-nitrico-neuronal-en-el-bulbo-olfatorio-del-raton\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"efectos-de-la-diferenciacion-en-la-expresion-de-la-sintasa-del-oxido-nitrico-neuronal-en-el-bulbo-olfatorio-del-raton","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efectos-de-la-diferenciacion-en-la-expresion-de-la-sintasa-del-oxido-nitrico-neuronal-en-el-bulbo-olfatorio-del-raton\/","title":{"rendered":"Efectos de la diferenciacion en la expresion de la sintasa del oxido nitrico neuronal en el bulbo olfatorio del raton."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Weruaga Prieto <\/strong><\/h2>\n<p>El \u00f3xido n\u00edtrico se genera mediante la acci\u00f3n enzim\u00e1tica de las sintasas del \u00f3xido n\u00edtrico (nos) y tiene un fisiolog\u00eda compleja en el sistema nervioso.  la expresi\u00f3n de nos se estudi\u00f3 en el bulbo olfatorio de dos estirpes de rat\u00f3n (balb\/c y cd1) que presentan diferencias en la sinaptolog\u00eda de sus glom\u00e9rulos. Mediante inmunohistoqu\u00edmica para la nos neuronal e histoqu\u00edmica para la nadph-diaforasa (nd) y su colocalizaci\u00f3n se determin\u00f3 en patr\u00f3n de distribuci\u00f3n de las neuronas productoras de \u00f3xido n\u00edtrico: c\u00e9lulas periglomerulares, c\u00e9lulas superficiales y profundas de ax\u00f3n corto y granos. El an\u00e1lisis cuantitativo de este patr\u00f3n demuestra diferentes densidades de periglomerulares alrededor de glom\u00e9rulos diferentes, definidos por la tinci\u00f3n nd, en ambas estirpes de rat\u00f3n. Esto implica una modulaci\u00f3n diferencial por parte del \u00f3xido n\u00edtrico en diversos tipos de glom\u00e9rulos olfatorios.  por primera vez se emple\u00f3 la inhalaci\u00f3n de bromometano a dosis espec\u00edficas para producir deaferenciaci\u00f3n olfatoria perif\u00e9rica. La inhalaci\u00f3n del gas produce degeneraci\u00f3n de los axones que sinaptan con las periglomerulares, demostrada con microscop\u00eda electr\u00f3nica, y mediante la comparaci\u00f3n cualitativa y cuantitativa de la expresi\u00f3n de tirosina hidroxilasa (th) en las dos estirpes. Tras la lesi\u00f3n, la expresi\u00f3n de th en las periglomerulares se reduce considerablemente en la estirpe cd1, pero no en la balb\/c. Tras 60 d\u00edas de supervivencia, este patr\u00f3n es similar al control. La expresi\u00f3n de nd en las periglomerulares presenta un comportamiento similar al de la th, con cambios detectables \u00fanicamente en la estirpe cd1, pero mucho m\u00e1s dram\u00e1ticos que para la th. El descenso en la expresi\u00f3n de nd es variable en distintas regiones topogr\u00e1ficas del bulbo olfatorio, llegando a producirse una p\u00e9rdida del marcaje de neuronas del 93%. Estos resultados indican que la expresi\u00f3n de la actividad nd depende de las afere<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la diferenciacion en la expresion de la sintasa del oxido nitrico neuronal en el bulbo olfatorio del raton.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la diferenciacion en la expresion de la sintasa del oxido nitrico neuronal en el bulbo olfatorio del raton. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Weruaga Prieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Aijon Noguera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel jose Gayoso rodriguez <\/li>\n<li>Fernando S\u00e1nchez hern\u00e1ndez (vocal)<\/li>\n<li>agustina Garc\u00eda s\u00e1nchez (vocal)<\/li>\n<li> Lara prada Juan  Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Weruaga Prieto El \u00f3xido n\u00edtrico se genera mediante la acci\u00f3n enzim\u00e1tica de las sintasas del \u00f3xido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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