{"id":40540,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neuroproteccion-frente-a-la-lesion-hipotalamica-inducida-por-glutamato-papel-de-los-receptores-ionotropos\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"neuroproteccion-frente-a-la-lesion-hipotalamica-inducida-por-glutamato-papel-de-los-receptores-ionotropos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/neuroproteccion-frente-a-la-lesion-hipotalamica-inducida-por-glutamato-papel-de-los-receptores-ionotropos\/","title":{"rendered":"Neuroproteccion frente a la lesion hipotalamica inducida por glutamato. papel de los receptores ionotropos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pe\u00f1a Luengo Luis Antonio <\/strong><\/h2>\n<p>Hemos realizado un estudio morfol\u00f3gico, cuantitativo e inmunohisto-qu\u00edmico de la lesi\u00f3n inducida por el glutamato monos\u00f3dico (4 mg\/kg de peso corporal, sc) sobre el n\u00facleo arcuato del hipot\u00e1lamo de la rata sprague-dawley, en per\u00edodo neonatal. asimismo, hemos utilizado antagonistas de los receptores nmda y ampa, y de los canales de calcio tipo-l, para analizar el grado de protecci\u00f3n neuronal alcanzado y, en consecuencia, dilucidar la participaci\u00f3n de dichos receptores y canales de calcio en el mecanismo de lesi\u00f3n. Los antagonistas empleados fueron el u-54494a (30 mg\/kg de peso corporal, sc) y el mk-801 (1 mg\/kg de peso corporal, ip) para los receptores nmda, el nbqx (60 mg\/kg de peso corporal, ip) para los ampa y el nimodipino (15 mg\/kg de peso corporal, ip) para los canales de calcio tipo-l. El sacrificio se realiz\u00f3 a las tres horas de la administraci\u00f3n del glutamato monos\u00f3dico. Para el estudio inmunohistoqu\u00edmico hemos utilizado antisueros frente a la tirosina hidroxilasa, a la glutamato decarboxilasa, al neurop\u00e9ptido y y a subunidades de los receptores ampa y nmda. A las tres horas de la administraci\u00f3n del glutamato los signos de degeneraci\u00f3n afectan a la mayor\u00eda de las neuronas del n\u00facleo arcuato, as\u00ed como a algunas neuronas del n\u00facleo ventromedial. Los antagonistas no causan lesi\u00f3n \u00abper se\u00bb. El mk-801, administrado cinco minutos antes o inmediatamente despu\u00e9s que el glutamato, consigue anular la degeneraci\u00f3n neuronal casi en su totalidad. La protecci\u00f3n aislada con u-54494a, nbqx y nimodipino no supera, en ning\u00fan caso, el 50%. La m\u00e1xima protecci\u00f3n se consigue con la administraci\u00f3n conjunta de mk-801 y nimodipino (97,5%). Tanto la lesi\u00f3n como la protecci\u00f3n de las diferentes poblaciones neuronales estudiadas, para los diferentes grupos experimentales, es inespec\u00edfica. Con los datos expuestos planteamos un mecanismo de lesi\u00f3n neurot\u00f3xica con la participaci\u00f3n de receptores ampa, nmda y ca<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neuroproteccion frente a la lesion hipotalamica inducida por glutamato. papel de los receptores ionotropos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neuroproteccion frente a la lesion hipotalamica inducida por glutamato. papel de los receptores ionotropos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pe\u00f1a Luengo Luis Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Luis Blazquez Arroyo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Amat mu\u00f1oz <\/li>\n<li>Antonio Raya romero (vocal)<\/li>\n<li>Elena Garcia sanchez (vocal)<\/li>\n<li>carmen Rojas laparte (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pe\u00f1a Luengo Luis Antonio Hemos realizado un estudio morfol\u00f3gico, cuantitativo e inmunohisto-qu\u00edmico de la lesi\u00f3n inducida por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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