{"id":40542,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/clonacion-y-caracterizacion-de-receptores-opioides-en-el-pez-cebra-danio-rerio\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"clonacion-y-caracterizacion-de-receptores-opioides-en-el-pez-cebra-danio-rerio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/clonacion-y-caracterizacion-de-receptores-opioides-en-el-pez-cebra-danio-rerio\/","title":{"rendered":"Clonacion y caracterizacion de receptores opioides en el pez cebra (danio rerio)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandro Barrallo Gimeno <\/strong><\/h2>\n<p>Los receptores opioides son las dianas end\u00f3genas de las sustancias opi\u00e1ceas y de los p\u00e9ptidos opioides y han sido ampliamente estudiados en mam\u00edferos, dada su evidente utilidad terap\u00e9utica en el control del dolor. Sin embargo, su presencia no ha sido totalmente establecida en vertebrados inferiores, aunque existen datos que apuntan a su existencia incluso en invertebrados. Por ello, como objetivo de este trabajo se propuso caracterizar por t\u00e9cnicas farmacol\u00f3gicas y moleculares los posibles receptores opioides en un tele\u00f3steo, el pez cebra (danio rerio).  como resultado de este trabajo se han identificado dos genes con alta homolog\u00eda con los receptores opioides de mam\u00edferos zfor1 presenta un 66% de identidad con el receptor opioide delta. La estructura gen\u00f3mica de este gen es muy similar a la de los receptores opioides delta de roedor y humano, con uniones ex\u00f3n-intr\u00f3n que se han conservado filogen\u00e9ticamente. La transfecci\u00f3n de su cdna en una l\u00ednea celular permiti\u00f3 la caracterizaci\u00f3n de sus propiedades farmacol\u00f3gicas, confirmando su naturaleza como receptor ipioide, aunque su clasificaci\u00f3n dentro de los tipos tradicionalmente considerados no ha sido totalmente establecida.  se identific\u00f3 un segundo gen, zfor2, que presenta un 74% de homolog\u00eda con el receptor opioide mu de mam\u00edferos y cuya estructura gen\u00f3mica es muy similar a la de \u00e9stos, aunque a diferencia de los receptores opioide mu de mam\u00edferos zfor2 carace del cuarto ex\u00f3n, que se ha implicado en procesos regulatorios.  la expresi\u00f3n de estos dos genes se ha estudiado mediante hibridaci\u00f3n in situ en el sistema nervioso del pez cebra, observando patrones de expresi\u00f3n ampliamente solapantes, aunque con zonas de expresi\u00f3n diferencial. En general, la expresi\u00f3n de estos genes se puede correlacionar con la observada para los distintos receptores opioides en el cerebro de mam\u00edferos.  por \u00faltimo, se analizaron los sitios de uni\u00f3n para sustanc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Clonacion y caracterizacion de receptores opioides en el pez cebra (danio rerio).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Clonacion y caracterizacion de receptores opioides en el pez cebra (danio rerio). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandro Barrallo Gimeno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raquel Emilia Rodr\u00edguez Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Fuentes jose <\/li>\n<li>Rafael Maldonado (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandro Barrallo Gimeno Los receptores opioides son las dianas end\u00f3genas de las sustancias opi\u00e1ceas y de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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