{"id":40556,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-implicados-en-el-efecto-relajante-del-dietilestilbestrol-en-aorta-aislada-de-rata\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"mecanismos-implicados-en-el-efecto-relajante-del-dietilestilbestrol-en-aorta-aislada-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-implicados-en-el-efecto-relajante-del-dietilestilbestrol-en-aorta-aislada-de-rata\/","title":{"rendered":"Mecanismos implicados en el efecto relajante del dietilestilbestrol en aorta aislada de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Martinez Alvarez <\/strong><\/h2>\n<p>El dietilestibestrol (des) produce vasorrelajaci\u00f3n. con objeto de dilucidar su mecanismo de acci\u00f3n, utilizando t\u00e9cnicas cl\u00e1sicas de \u00f3rgano aislado, se ha investigado la relajaci\u00f3n inducida por el des en tiras de aorta precontra\u00eddas por la noradrenalina. Se ensay\u00f3 la reversi\u00f3n por el lavado, por el aumento de la concentraci\u00f3n de calcio y por el bay k 8644. Se estudio el efecto de antagonistas de los receptores beta-adren\u00e9rgicos y purin\u00e9rgicos, antagonistas del receptor estrog\u00e9nico, inhibidores de la transcripci\u00f3n y de la s\u00edntesis proteica, inhibidor de las prote\u00ednas gi, bloqueantes de los canales de potasio, inhibidores de la adenilato ciclasa, de la guanilato ciclasa, de la prote\u00edna quinasa a, de la prote\u00edna quinasa c y de la tirosina quinasa, e inhibidor de la s\u00edntesis de poliaminas. Se investig\u00f3 la contribuci\u00f3n del endotelio y del sexo de los animales. nuestros resultados demuestran que el des produce relajaci\u00f3n concentraci\u00f3n-dependiente por acci\u00f3n en las c\u00e9lulas endoteliales y en el m\u00fasculo liso vascular. En las c\u00e9lulas del endotelio el efecto est\u00e1 relacionado con el \u00f3xido n\u00edtrico, y para que se produzca es necesario que las aortas procedan de animales sexualmente completos, siendo mayor en aortas de ratas hembras que en ratas macho. El efecto en el m\u00fasculo liso vascular no est\u00e1 relacionado con mecanismos calcio-dependientes, participa un receptor de membrana y se encuentran implicadas dos v\u00edas de transducci\u00f3n que tienen en com\u00fan la activaci\u00f3n de la prote\u00edna quinasa ampc dependiente (pka). Una depende de la apertura de canales de potasio sensibles a la glibenclamida e implica la participaci\u00f3n de las poliaminas end\u00f3genas; y la otra est\u00e1 relacionada con la transcripci\u00f3n gen\u00f3mica. Este efecto a nivel de m\u00fasculo liso no se modifica por el sexo de los animales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos implicados en el efecto relajante del dietilestilbestrol en aorta aislada de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos implicados en el efecto relajante del dietilestilbestrol en aorta aislada de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Martinez Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garcia De Boto M. Jose<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Velasco martin <\/li>\n<li>rosal\u00eda Carr\u00f3n de la calle (vocal)<\/li>\n<li>agustin Hidalgo balsera (vocal)<\/li>\n<li>angel Alvarez sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Martinez Alvarez El dietilestibestrol (des) produce vasorrelajaci\u00f3n. con objeto de dilucidar su mecanismo de acci\u00f3n, utilizando [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,483,9386,8334],"tags":[9017,12654,92342,50207,103392,39332],"class_list":["post-40556","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-mecanismos-de-accion-de-los-farmacos","category-salamanca","category-ubicacion-activa-y-receptores","tag-agustin-hidalgo-balsera","tag-alfonso-velasco-martin","tag-angel-alvarez-sanchez","tag-carmen-Martinez-alvarez","tag-garcia-de-boto-m-jose","tag-rosalia-carron-de-la-calle"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40556"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40556\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}