{"id":40644,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alcaloides-de-las-especies-rauwolfia-sprucei-stemmadenia-obovata-delphinium-cardiopetalum-y-withania-aristata-contribucion-a-la-quimica-de-los-alcaloides-tipo-iboga\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"alcaloides-de-las-especies-rauwolfia-sprucei-stemmadenia-obovata-delphinium-cardiopetalum-y-withania-aristata-contribucion-a-la-quimica-de-los-alcaloides-tipo-iboga","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/alcaloides-de-las-especies-rauwolfia-sprucei-stemmadenia-obovata-delphinium-cardiopetalum-y-withania-aristata-contribucion-a-la-quimica-de-los-alcaloides-tipo-iboga\/","title":{"rendered":"Alcaloides de las especies, rauwolfia sprucei, stemmadenia obovata, delphinium cardiopetalum y withania aristata. contribucion a la quimica de los alcaloides tipo iboga."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Madinaveitia Martin <\/strong><\/h2>\n<p>De la rauwolfia sprucei se aislaron 8 bases conocidas de las cuales la perakina y la compactinervina son aislados por primera vez en el g\u00e9nero rauwolfia. Destaca en esta planta el alto contenido en alcaloides cuaternarios (2.3% respecto del peso seco).  la stenmadenia obovata suministr\u00f3 14 alcaloides de los cuales tres, la ajmalicina, ajmalicinina y su ep\u00edmero en c-17, son aislados por primera vez del g\u00e9nero y otros tres obovamina, obovatina, n(1)-metil-11-hidroximalusina a, fueron alcaloides no descritos en la bibliograf\u00eda:  la obovamina, es un aza acetal tipo iboga cuya estructura se determin\u00f3 inequ\u00edvocamente mediante s\u00edntesis parcial a partir del producto mayoritario de la planta, la voacangina. Adem\u00e1s este compuesto se demostr\u00f3 que es un artefacto producido por la autoxidaci\u00f3n de la voacangina, durante el proceso de extracci\u00f3n.  la n(1)-metil-11-hidroxi-macusina a, es un alcaloide cuaternario tipo sarpagina, minoritario en la planta, cuya estructura se estableci\u00f3 mediante el estudio de sus datos espectrosc\u00f3picos y por comparaci\u00f3n con los de compuestos similares tales como los aislados por nosotros de la rauwolfia sprucei.  la obovatina es un nuevo alcaloide bisind\u00f3lico tipo ibogo cuya estructura se estableci\u00f3 inequ\u00edvocamente mediante s\u00edntesis parcial a partir de la bis (11-hidroxi-coronaridin)-12 ilo. Dado que alcaloides bisind\u00f3licos tales como la vinblastina y vincristina presentan importantes actividades antitumorales, la obovamina fue sometida a ensayos de citotoxicidad resultando sin embargo todos ellos negativos.  del delphinium cardiopetalum, se aislaron 13 nuevas bases:  el extracto b\u00e1sico rindi\u00f3 los alcaloides cardionidina, el primer alcaloide diterp\u00e9nico en contener una funci\u00f3n anh\u00eddrido en su esqueleto cuya estructura se estableci\u00f3 deforma inequ\u00edvoca mediante estudios de difracci\u00f3n de rayos x y la cossonidina, mientras que los extractos \u00e1cidos rindieron 5 nuevos alcaloides diterp\u00e9nico<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alcaloides de las especies, rauwolfia sprucei, stemmadenia obovata, delphinium cardiopetalum y withania aristata. contribucion a la quimica de los alcaloides tipo iboga.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alcaloides de las especies, rauwolfia sprucei, stemmadenia obovata, delphinium cardiopetalum y withania aristata. contribucion a la quimica de los alcaloides tipo iboga. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Madinaveitia Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Gonzalez Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Gutierrez ravelo <\/li>\n<li>braulio Manuel Fraga gonz\u00e1lez (vocal)<\/li>\n<li>pedro Gonzalez garcia (vocal)<\/li>\n<li>Jaime Bastida armengol (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Madinaveitia Martin De la rauwolfia sprucei se aislaron 8 bases conocidas de las cuales la perakina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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