{"id":40672,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-morfogenico-del-receptor-d1-dopaminergico-durante-el-desarrollo-cerebral-implicaciones-en-la-esquizofrenia\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"papel-morfogenico-del-receptor-d1-dopaminergico-durante-el-desarrollo-cerebral-implicaciones-en-la-esquizofrenia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-morfogenico-del-receptor-d1-dopaminergico-durante-el-desarrollo-cerebral-implicaciones-en-la-esquizofrenia\/","title":{"rendered":"Papel morfogenico del receptor d1 dopaminergico durante el desarrollo cerebral. implicaciones en la esquizofrenia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gustavo Sajnani Perez <\/strong><\/h2>\n<p>En un intento de unificar la hip\u00f3tesis dopamin\u00e9rgica (que supone una hiperactividad del sistema l\u00edmbico dopamin\u00e9rgico) de la esquizofrenia con la hip\u00f3tesis del neurodesarrollo (que supone un trastorno del desarrollo normal de cerebro) a trav\u00e9s de los efectos morfog\u00e9nicos de los receptores de monoaminas, se analiz\u00f3 el efecto de la administraci\u00f3n pre\/posnatal de un agonista d1 dopamin\u00e9rgico (skf-38393-n allyl) a una dosis de 0,03 mg\/kg sobre los niveles de monoaminas en diferentes \u00e1reas cerebrales. Los resultados obtenidos mostraron una alteraci\u00f3n del metabolismo de la dopamina y la serotonina en \u00e1reas l\u00edmbicas (accumbens, am\u00edgdala e hipocampo) tras el tratamiento prenatal. Tambi\u00e9n se hall\u00f3 una reducci\u00f3n en el n. De terminales de 5ht en el \u00e1rea ca1 del hipocampo dorsal y una disminuci\u00f3n en la expresi\u00f3n del marcador de maduraci\u00f3n sin\u00e1ptica gaap-43 tras el tratamiento prenatal.  las alteraciones que se producen durante el desarrollo en las interacciones morfog\u00e9nicas de los neurotransmisores dopaminay serotonina pueden ser cr\u00edticas para la determinaci\u00f3n a largo plazo de cambios neuroanat\u00f3micos y funcionales espec\u00edficos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel morfogenico del receptor d1 dopaminergico durante el desarrollo cerebral. implicaciones en la esquizofrenia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel morfogenico del receptor d1 dopaminergico durante el desarrollo cerebral. implicaciones en la esquizofrenia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gustavo Sajnani Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Castro Fuentes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gundela Meyer <\/li>\n<li>Jos\u00e9 Regidor Garc\u00eda (vocal)<\/li>\n<li>miquel Casas brugue (vocal)<\/li>\n<li>pedro Abreu gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gustavo Sajnani Perez En un intento de unificar la hip\u00f3tesis dopamin\u00e9rgica (que supone una hiperactividad del sistema [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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