{"id":40716,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-marcadores-biologicos-en-el-carcinoma-infiltrante-de-mama-correlacion-con-los-factores-pronosticos-clasicos\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"nuevos-marcadores-biologicos-en-el-carcinoma-infiltrante-de-mama-correlacion-con-los-factores-pronosticos-clasicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevos-marcadores-biologicos-en-el-carcinoma-infiltrante-de-mama-correlacion-con-los-factores-pronosticos-clasicos\/","title":{"rendered":"Nuevos marcadores biologicos en el carcinoma infiltrante de mama. correlacion con los factores pronosticos clasicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Carmen Gonzalez Vela <\/strong><\/h2>\n<p>La identificaci\u00f3n de factores pron\u00f3sticos quer predigan con seguridad el comportamiento biol\u00f3gico del carcinoma de mama (cm) es fundamental para un tratamiento apropiado de las pacientes. El estado de los gamglios linf\u00e1ticos axilares (gla) es uno de los f actores pron\u00f3sticos cl\u00e1sicos m\u00e1s importantes. Sin embargo su afectaci\u00f3n no siempre predice el pron\u00f3stico exactamente. Esto ha conducido a la b\u00fasqueda de nuevos factores pron\u00f3sticos como la sobre expresi\u00f3n y\/o amplificaci\u00f3n de oncogenes, la expresi\u00f3n de factores de crecimiento, diversos par\u00e1metros de proliferaci\u00f3n celular y marcadores relacionados con la diseminaci\u00f3n y met\u00e1stasis de las c\u00e9lulas tumorales. Sin embargo, la utilidad cl\u00ednica de todos estos factores no est\u00e1 definitivamente establecida.  nuestros objetivos fueron: i) determinar que relaci\u00f3n existe entre los nuevos marcadores biol\u00f3gicos y los factores pron\u00f3sticos cl\u00e1sicos e ii) intentar predecir el estado de afectaci\u00f3n de los gla utilizando una combinaci\u00f3n de los marcadores biol\u00f3gicos nuevos y los cl\u00e1sicos.  estudio prospectivo de 102 mujeres con cm infiltrante primario diagnosticados entre 1994 y 1995. El tratamiento quir\u00fargico consisti\u00f3  en mastectomia o cuadrantectomia m\u00e1s disecci\u00f3n ganglionar axilar. Todas las piezas quir\u00fargicas se recibieron en fresco, midi\u00e9ndose el di\u00e1metro tumoral m\u00e1ximo y se congel\u00f3 un fragmento tumoral para estudio de citometria de flujo, determin\u00e1ndose la ploidia del adn, el porcentaje de c\u00e9lulas en fase s (pcfs) y el \u00edndice de proliferaci\u00f3n celular. En los cortes histol\u00f3gicos tumorales te\u00f1idos con hematoxilinaeosina se determinaron: tipo histol\u00f3gico, grado nuclear (black), margen de crecimiento, mitosis en 1000 c\u00e9lulas, invasi\u00f3n vascular y presencia o no de gla metastatizados. Se efectu\u00f3 estudio inmunohistoqu\u00edmico segun el m\u00e9todo peroxidasa-antiperoxidasa utilizando los siguientes anticuerpos monoclonales. Receptores de estr\u00f3geno (re), receptores de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos marcadores biologicos en el carcinoma infiltrante de mama. correlacion con los factores pronosticos clasicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos marcadores biologicos en el carcinoma infiltrante de mama. correlacion con los factores pronosticos clasicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Carmen Gonzalez Vela <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garijo Ayensa M. Francisca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 fernando Val bernal <\/li>\n<li>Jos\u00e9 Mar\u00eda Rivera pomar (vocal)<\/li>\n<li>agustin Herrero zapatero (vocal)<\/li>\n<li> Villar negro araceli del (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Carmen Gonzalez Vela La identificaci\u00f3n de factores pron\u00f3sticos quer predigan con seguridad el comportamiento biol\u00f3gico del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10518,9,189,1027,156],"tags":[9185,10629,10583,13350,103674,103675],"class_list":["post-40716","post","type-post","status-publish","format-standard","hentry","category-cantabria","category-ciencias-medicas","category-farmacodinamia","category-oncologia","category-patologia","tag-agustin-herrero-zapatero","tag-garijo-ayensa-m-francisca","tag-jose-fernando-val-bernal","tag-jose-maria-rivera-pomar","tag-maria-carmen-gonzalez-vela","tag-villar-negro-araceli-del"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40716","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40716"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40716\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}