{"id":40725,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-de-la-eficacia-de-la-nimodipina-para-reducir-las-necesidades-de-morfina-en-pacientes-con-dolor-cronico-oncologico\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"valoracion-de-la-eficacia-de-la-nimodipina-para-reducir-las-necesidades-de-morfina-en-pacientes-con-dolor-cronico-oncologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valoracion-de-la-eficacia-de-la-nimodipina-para-reducir-las-necesidades-de-morfina-en-pacientes-con-dolor-cronico-oncologico\/","title":{"rendered":"Valoracion de la eficacia de la nimodipina para reducir las necesidades de morfina en pacientes con dolor cronico oncologico."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Santillan Fernandez M. Rosa <\/strong><\/h2>\n<p>El objetivo de este estudio fue verificar en humanos la capacidad de la nimodipina (antagonista del calcio dihidropirid\u00ednico) para reducir la dosis diaria de morfina necesaria para aliviar el dolor. Se realiz\u00f3 un estudio abierto y posteriormente un ensayo doble ciego, randomizado y controlado con placebo en pacientes con dolor cr\u00f3nico oncol\u00f3gico que hubieran desarrollado una escalada en la dosis de morfina.  de los 23 pacientes que se reclutaron en el estudio abierto, en 16 pacientes se pudo disminuir significativamente la dosis de morfina (282+-47,8 a 158+-26,2 mg\/d\u00eda) (p&lt;0,001); 2 enfermos respondieron negativamente y hubo 5 abandonos. Un total de 30 pacientes completaron el estudio doble ciego, 14 del grupo nimodipina (n) y 16 del placebo (p). La nipodipina fue eficaz reduciendo la dosis de morfina en . Pcientes (65%) mientras que al placebo respondieron 4 (25%), siendo la diferencia estad\u00edsticamente significativa.  la dosis de morfina se redujo significativamente en el grupo n desde 313+-52 a 174+-33 mg d\u00eda (p&lt;0,001) mientras que no vari\u00f3 en el grupo p (254+-26 a 218+-19 mg\/d\u00eda. La diferencia de los porcentajes de reducci\u00f3n de la dosis diarias de morfina tambi\u00e9n fue significativa entre ambos grupos (p=0,002). No hubo modificaciones significativas los niveles en sangre de morfina ni de sus metabolitos (m-6-g y m-3-g) en 14 pacientes (6 grupos n y 8 del p) una semana despu\u00e9s de introducir la nimodipina o el placebo asociado a la morfina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoracion de la eficacia de la nimodipina para reducir las necesidades de morfina en pacientes con dolor cronico oncologico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoracion de la eficacia de la nimodipina para reducir las necesidades de morfina en pacientes con dolor cronico oncologico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Santillan Fernandez M. Rosa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Florez Beledo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Armijo simon <\/li>\n<li>Luis Aliaga font (vocal)<\/li>\n<li>gumersindo Solares gonzalez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Santillan Fernandez M. Rosa El objetivo de este estudio fue verificar en humanos la capacidad de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10518,155,9,957,25911,347],"tags":[103691,9872,10699,34812,103690],"class_list":["post-40725","post","type-post","status-publish","format-standard","hentry","category-cantabria","category-ciencias-clinicas","category-ciencias-medicas","category-farmacologia","category-medicina-paliativa","category-oncologia-clinica","tag-gumersindo-solares-gonzalez","tag-jesus-florez-beledo","tag-juan-antonio-armijo-simon","tag-luis-aliaga-font","tag-santillan-fernandez-m-rosa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40725"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40725\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}