{"id":40757,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-y-reacciones-de-isotiocianato-y-aza-anhidroazucares\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"sintesis-y-reacciones-de-isotiocianato-y-aza-anhidroazucares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-y-reacciones-de-isotiocianato-y-aza-anhidroazucares\/","title":{"rendered":"Sintesis y reacciones de isotiocianato- y aza -anhidroazucares."},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Olano Gibouin <\/strong><\/h2>\n<p>Esta tesis doctoral se encuadr\u00f3 dentro de dos proyectos de investigaci\u00f3n. El primero sobre isotiocianato, tioamino- y sulfoaminoaz\u00facares; el segundo sobre azaaz\u00facares, nucle\u00f3sidos, glicol\u00edpidos y precursores qu\u00edmicos.  seg\u00fan esto la tesis se ha dividido en dos cap\u00edtulos. isotiocianatoaz\u00facares y azaanhidroaz\u00facares.  los isotiocianatoaz\u00facares son compuestos muy vers\u00e1tiles como bloques sint\u00e9ticos, debido a la reactividad del grupo isotiocianato, y tambi\u00e9n son \u00fatiles como moldes o auxiliares quirales en s\u00edntesis asim\u00e9trica debido al anillo de az\u00facar. En este trabajo experimental se ha desarrollado un m\u00e9todo para la obtenci\u00f3n de derivados en los que el grupo isotiocianato se encuentra en las posiciones dos, tres o cuatro de un anillo de az\u00facar con configuraci\u00f3n d-mano, d-alo y d-gluco respectivamente.  con respecto a los azaanhidroaz\u00facares se han empleado como compuesto vers\u00e1tiles para la s\u00edntesis de iminociclitoles de cinco y siete v\u00e9rtices. El procedimiento se ha basado en el grupo dietoxicarbonilvinilo que se usa como n-protector y como estabilizador de un ion amiduro, el cual produce una reacci\u00f3n de sustituci\u00f3n nucle\u00f3fila intramolecular, form\u00e1ndose los 1,4- 1,6 -azaanhidroaz\u00facares. La transformaci\u00f3n de estos por rotura selectiva de un enlace produce 4- enaminoaldosas, polihidroxipirrolidinas y polihidroxiperhidroazepanos. Los iminociclitoles son compuestos muy interesantes tanto biol\u00f3gica como farmaceuticamente al haber sido identificados como componentes de la estructura de diferentes antibioticos y furgicidas. Tambi\u00e9n son inhibidores de glicosidasas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y reacciones de isotiocianato- y aza -anhidroazucares.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y reacciones de isotiocianato- y aza -anhidroazucares. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Olano Gibouin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Fuentes Mota<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Castedo exposito <\/li>\n<li>Mar\u00eda na Trujillo perez-lanzac (vocal)<\/li>\n<li> Merchan alvarez Francisco Luis (vocal)<\/li>\n<li>eleuterio \u00e1lvarez gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Olano Gibouin Esta tesis doctoral se encuadr\u00f3 dentro de dos proyectos de investigaci\u00f3n. El primero sobre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1412,17,3209,416,10715],"tags":[103741,103744,10975,568,103742,103743],"class_list":["post-40757","post","type-post","status-publish","format-standard","hentry","category-compuestos-heterociclicos","category-quimica","category-quimica-de-los-hidratos-de-carbono","category-quimica-organica","category-sevilla","tag-david-olano-gibouin","tag-eleuterio-alvarez-gonzalez","tag-jose-fuentes-mota","tag-luis-castedo-exposito","tag-maria-na-trujillo-perez-lanzac","tag-merchan-alvarez-francisco-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40757"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40757\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40757"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}