{"id":40780,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-simvastatina-sobre-la-funcion-endotelial-importancia-del-endotelio\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"efecto-de-simvastatina-sobre-la-funcion-endotelial-importancia-del-endotelio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-simvastatina-sobre-la-funcion-endotelial-importancia-del-endotelio\/","title":{"rendered":"Efecto de simvastatina sobre la funcion endotelial: importancia del endotelio."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Alvarez De Sotomayor Paz <\/strong><\/h2>\n<p>Simvastina fue capaz de relajar los anillos de aorta aislada de rata por un mecanismo endotelio-dependiente posiblemente debido a un incremento de la actividad nosintasa. El origen del efecto parece ser debido a su actividad inhibidora de la hmg-co a reducta al disminuir la concentraci\u00f3n de isprenoides. Otros factores est\u00e1n implicados en la acci\u00f3n vasodilatadora de simvastatina como los derivados de la cox, el edhf y radicales libres oxigenados. El efecto endotelial est\u00e1 asociado a la activaci\u00f3n de la tirosina kinasa. La arteria mesent\u00e9rica se muestra m\u00e1s sensible y con un comportamiento similar al observado en la aorta.  en c\u00e9lulas endoteliales, simvastantina incrementa el cacio citos\u00f3lico activando la nosintasa y la pla2.  los mecanismos implicados son la entrada de calcio del medio extracelular, la liberaci\u00f3n de dep\u00f3sitos sensibles a tapsigargina, y rianodina, as\u00ed como la implicaci\u00f3n de la hmg-co a reductasa y las proteinas rho.  el tratamiento cr\u00f3nico con simvastina de ratas hipertensas, mejor\u00f3 la funci\u00f3n endotelial por una mayor participaci\u00f3n de la nosintasa que de los factores derivados de la cox. Simvastatina tambien produce una normalizaci\u00f3n de la respuesta contr\u00e1ctil a ouabina, inhibidor de la bomba sodio-potaso, pudiendo atribuir dicho efecto a una regulaci\u00f3n de los procesos homeost\u00e1ticosd del calcio en c\u00e9lula.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de simvastatina sobre la funcion endotelial: importancia del endotelio.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de simvastatina sobre la funcion endotelial: importancia del endotelio. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Alvarez De Sotomayor Paz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elisa Marhuenda Requena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Bravo diaz <\/li>\n<li>joaqu\u00edn Carneado de la fuente (vocal)<\/li>\n<li>domingo Martin herrera (vocal)<\/li>\n<li>Mar\u00eda   teresa Tejerina sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Alvarez De Sotomayor Paz Simvastina fue capaz de relajar los anillos de aorta aislada de rata [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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