{"id":40781,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-la-melatonina-en-la-gastropatia-inducida-por-isquemia-reperfusion-en-rata-mecanismos-implicados\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"influencia-de-la-melatonina-en-la-gastropatia-inducida-por-isquemia-reperfusion-en-rata-mecanismos-implicados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-de-la-melatonina-en-la-gastropatia-inducida-por-isquemia-reperfusion-en-rata-mecanismos-implicados\/","title":{"rendered":"Influencia de la melatonina en la gastropatia inducida por isquemia reperfusion en rata: mecanismos implicados."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cabeza Valle Juan  Francisco <\/strong><\/h2>\n<p>En la presente memoria, se ha valorado el efecto protector de la hormona melatonina (5,10 y 20 mg\/kg) en un modelo de ulcerog\u00e9nesis g\u00e1strica provocada por isquemia inducida por oclusi\u00f3n de la arteria cel\u00edaca durante 30 minutos seguida de 60 minutos de reperfusi\u00f3n en ratas. la melatonina reduce la incidencia y gravedad del da\u00f1o. la valoraci\u00f3n microsc\u00f3pica de las lesiones confirma los resultados obtenidos en el estudio macrosc\u00f3pico. Los ensayos bioqu\u00edmicos corroboran el potente efecto antilipoperoxidante de la hormona al reducir dr\u00e1sticamente los niveles de malonildialdehido. La actividad xantin oxidasa de mucosas sometidas a isquemia-reperfusi\u00f3n resultaron ser significativamente m\u00e1s elevados que los referentes a animales sanos y el tratamiento con melatonina fue capaz de restablecer los valores normales. La presencia de un importante componente inflamatorio asociado a las lesiones inducidas por isquemia-reperfusi\u00f3n es reducida por melatonina, como pudimos observar cuantificando la actividad del enzima mieloperoxidas. Asimismo, la hormona pineal podr\u00eda contrarrestar la disminuci\u00f3n en la actividad de las enzimas antioxidantes (super\u00f3xido dismutasa, glutation peroxidasa y glutation reductasa) observada en animales isqu\u00e9micos reperfundidos. En mucosas sometidas al proceso quir\u00fargico observamos una caida significativa de la actividad de la enzima \u00f3xido n\u00edtrico sintetasa y en los niveles tisulares de gmpc. La administraci\u00f3n de la hormona no modifica estos par\u00e1metros. la medida realizada de los niveles de prostaglandina e2 nos indican la capacidad de la hormona en promover un incremento del eicosanoide de forma dosis dependiente.  el estudio sobre la influencia de la exposici\u00f3n a la luz previa al experimento, nos permiten proponer que la acci\u00f3n de la hormona, ligada a su potente actividad antioxidante, requiere adem\u00e1s ciertos cambios adaptativos que estar\u00edan influidos por las condiciones del fotoper\u00edodo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de la melatonina en la gastropatia inducida por isquemia reperfusion en rata: mecanismos implicados.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de la melatonina en la gastropatia inducida por isquemia reperfusion en rata: mecanismos implicados. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cabeza Valle Juan  Francisco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Catalina Alarcon De La Lastra Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Sanchez de la cuesta felipe <\/li>\n<li>Luis Bravo diaz (vocal)<\/li>\n<li> Esplugues mota Juan  vicente (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cabeza Valle Juan Francisco En la presente memoria, se ha valorado el efecto protector de la hormona [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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