{"id":40786,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacoquimico-de-retama-sphaerocarpa-boissier\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-farmacoquimico-de-retama-sphaerocarpa-boissier","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacoquimico-de-retama-sphaerocarpa-boissier\/","title":{"rendered":"Estudio farmacoquimico de retama sphaerocarpa boissier."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Lopez Lazaro <\/strong><\/h2>\n<p>Han sido investigado aspectos qu\u00edmicos y farmacol\u00f3gicos de retama sphaerocarpa boissier, bas\u00e1ndonos en estudios previos realizados en nuestro laboratorio que demostraban que esta especie pose\u00eda actividad citost\u00e1tica.  como resultado de dicha investigaci\u00f3n se han aislado por m\u00e9todos cromatogr\u00e1ficos siete compuestos flavonoides, que han sido identificados por tecnicas espectrosc\u00f3picas y transformaciones qu\u00edmicas; tres isoflavonas, una flavona y los restantes flavonoles, destacando que tres de estos siete compuestos han sido descritos por vez primera por nuestro grupo de investigaci\u00f3n.  se ha estudiado la actividad antiumoral de los compuestos aislados, as\u00ed como la de sus extractos de procedencia, en las lineas tumorales humanas tk-10,uacc-62 y mcf-7, demostrando actividad todos ellos en al menos una de las tres lineas celulares. posteriormente, para ver posibles mecanismos de acci\u00f3n implicados en esta actividad, se evalu\u00f3 la capacidad de estos flavonoides de envenenar in vitro las topoisomerasas humanas tipo i y ii, encontr\u00e1ndose actividad positiva en cinco de ellos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacoquimico de retama sphaerocarpa boissier.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacoquimico de retama sphaerocarpa boissier. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Lopez Lazaro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Ayuso Gonzalez M. Jes\u00fas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Bravo diaz <\/li>\n<li>felipe Cortes benavides (vocal)<\/li>\n<li>diego m. Cortes mart\u00ednez (vocal)<\/li>\n<li>\u00e1ngeles Gato gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Lopez Lazaro Han sido investigado aspectos qu\u00edmicos y farmacol\u00f3gicos de retama sphaerocarpa boissier, bas\u00e1ndonos en estudios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,35,9,9399,489,957,17,457,10715],"tags":[35006,10425,2514,13753,22802,103792],"class_list":["post-40786","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-de-la-vida","category-ciencias-medicas","category-cultivo-celular","category-farmacognosia","category-farmacologia","category-quimica","category-quimica-farmaceutica","category-sevilla","tag-angeles-gato-gonzalez","tag-ayuso-gonzalez-m-jesus","tag-diego-m-cortes-Martinez","tag-felipe-cortes-benavides","tag-luis-bravo-diaz","tag-miguel-lopez-lazaro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40786","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40786"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40786\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40786"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40786"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40786"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}