{"id":40834,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/umbral-de-percolacion-como-parametro-de-preformulacion-en-la-elaboracion-de-sistemas-matriciales-de-liberacion-controlada\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"umbral-de-percolacion-como-parametro-de-preformulacion-en-la-elaboracion-de-sistemas-matriciales-de-liberacion-controlada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/umbral-de-percolacion-como-parametro-de-preformulacion-en-la-elaboracion-de-sistemas-matriciales-de-liberacion-controlada\/","title":{"rendered":"Umbral de percolacion como parametro de preformulacion en la elaboracion de sistemas matriciales de liberacion controlada."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Melgoza Contreras Luz M. <\/strong><\/h2>\n<p>La teor\u00eda de la percolaci\u00f3n es una teor\u00eda multidisciplinaria que estudia sistemas desordenados o ca\u00f3ticos cuyos componentes est\u00e1n distribuidos aleatoriamente en una red (leuenberger et al., 1987; stauffer y anarony, 1992, cap. 1). El umbral de percolaci\u00f3n es uno de los par\u00e1metros m\u00e1s importantes que ha aportado la teor\u00eda de la percolaci\u00f3n (domb, 1983; stauffer y aharony, 1992, cap. 1). as\u00ed, el umbral de percolaci\u00f3n se define como la concentraci\u00f3n de un componente a la cual existe la m\u00e1xima probabilidad de obtener por primera vez un \u00abcluster\u00bb infinito de dicha sustancia. En la presente tesis doctoral se estiman los umbrales de percolaci\u00f3n de f\u00e1rmaco\/excipiente en los sistemas matriciales clorhidrato de naltrexona\/eudragit rspm, clorhidrato de morfina\/eudragit rspm, clorhidrato de morfina \/ ethocel 100 y bromhidrato de dextrometorfano\/eudragit rspm. Conociendo que uno de los principales inconvenientes de las matrices inertes es que la liberaci\u00f3n de f\u00e1rmaco no es constante. Se ha observado que cuando estas matrices se recubren con parafina, dejando una sola cara para la liberaci\u00f3n, existen periodos extensos de orden cero. En este apartado pretendemos conseguir periodos de liberaci\u00f3n constante cubriendo parcialmente matrices inertes de kci\/eudragit rspm con una soluci\u00f3n de eudragit 100. Finalmente se estudian algunos factores que pudieran influir en el umbral de percolaci\u00f3n del f\u00e1rmaco observ\u00e1ndose que el tama\u00f1o de part\u00edcula relativo influye m\u00e1s notablemente sobre el umbral de percolaci\u00f3n. El porcentaje de comprensibilidad y el factor de forma ejercen una influencia menos significativa y finalmente la prosidad inicial, resistencia a la fractura corregida, peso molecular y solubilidad no muestran influencia significativa.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Umbral de percolacion como parametro de preformulacion en la elaboracion de sistemas matriciales de liberacion controlada.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Umbral de percolacion como parametro de preformulacion en la elaboracion de sistemas matriciales de liberacion controlada. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Melgoza Contreras Luz M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Rabasco Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Alonso hernandez m. jose <\/li>\n<li>mercedes Fernandez arevalo (vocal)<\/li>\n<li>sergio Pinzauti (vocal)<\/li>\n<li>\u00e1ngel Mu\u00f1oz ru\u00edz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Melgoza Contreras Luz M. La teor\u00eda de la percolaci\u00f3n es una teor\u00eda multidisciplinaria que estudia sistemas desordenados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957,3304,10715],"tags":[103877,40316,11840,103876,54476,103878],"class_list":["post-40834","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-preparacion-de-farmacos","category-sevilla","tag-alonso-hernandez-m-jose","tag-angel-munoz-ruiz","tag-antonio-rabasco-alvarez","tag-melgoza-contreras-luz-m","tag-mercedes-fernandez-arevalo","tag-sergio-pinzauti"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40834"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40834\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}