{"id":40904,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/citogenetica-molecular-en-el-estudio-de-la-leucemia-linfatica-cronica\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"citogenetica-molecular-en-el-estudio-de-la-leucemia-linfatica-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/citogenetica-molecular-en-el-estudio-de-la-leucemia-linfatica-cronica\/","title":{"rendered":"Citogenetica molecular en el estudio de la leucemia linfatica cronica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Blanca Navarro Cubells <\/strong><\/h2>\n<p>Las alteraciones estructurales del cromosoma 13 son las anomal\u00edas cromos\u00f3micas m\u00e1s frecuentes en la leucemia linf\u00e1tica cr\u00f3nica (llc). Existen dos puntos de ruptura: 13q12, 13q14 en las que podr\u00eda ubicarse un gen supresor de tumores con relevancia en la etiopatogenia de la llc. En 13q12 se localiza el gen de susceptibilidad hereditaria al c\u00e1ncer de mama brca2. Este gen se encuentra delecionado en el 58% de los casos con llc y parecen presentar una relaci\u00f3n estad\u00edsticamente significativa con la morfolog\u00eda at\u00edpica y el estudio cl\u00ednico avanzado. Su aparici\u00f3n en subclonas minoritarias indica que se trata de una alteraci\u00f3n gen\u00e9tica secundaria relacionada con la progresi\u00f3n de la enfermedad.  las deleciones en 13q14 y la trisomia 12 son tambi\u00e9n anomal\u00edas secundarias, y aparecen simult\u00e1neamente en el 46% de los casos, presentando una distribuci\u00f3n heterog\u00e9nea. Los estudios de significaci\u00f3n cl\u00ednica indican que existe una correlaci\u00f3n cl\u00ednica evidente de modo que las deleciones d13525 (en 13q14) parecen conferir un buen pron\u00f3stico y las deleciones del gen retinoblastoma se asocian a la refractariedad al tratamiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Citogenetica molecular en el estudio de la leucemia linfatica cronica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Citogenetica molecular en el estudio de la leucemia linfatica cronica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Blanca Navarro Cubells <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Garcia Marco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garc\u00eda conde bru javier <\/li>\n<li> Fernandez rodriguez Manuel n. (vocal)<\/li>\n<li>felix Carbonell ramon (vocal)<\/li>\n<li> Armengod gonzalez Mar\u00eda  e. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Blanca Navarro Cubells Las alteraciones estructurales del cromosoma 13 son las anomal\u00edas cromos\u00f3micas m\u00e1s frecuentes en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,11771,347],"tags":[104013,104010,39952,104012,11726,104011],"class_list":["post-40904","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-genetica-clinica","category-oncologia-clinica","tag-armengod-gonzalez-maria-e","tag-blanca-navarro-cubells","tag-felix-carbonell-ramon","tag-fernandez-rodriguez-manuel-n","tag-garcia-conde-bru-javier","tag-jose-garcia-marco"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40904","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40904"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40904\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40904"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40904"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40904"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}