{"id":40912,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-de-la-conectividad-molecular-para-la-busqueda-de-nuevos-hipoglucemiantes-orales\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"aplicacion-de-la-conectividad-molecular-para-la-busqueda-de-nuevos-hipoglucemiantes-orales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aplicacion-de-la-conectividad-molecular-para-la-busqueda-de-nuevos-hipoglucemiantes-orales\/","title":{"rendered":"Aplicacion de la conectividad molecular para la busqueda de nuevos hipoglucemiantes orales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Calabuig Ramon <\/strong><\/h2>\n<p>Se ha aplicado el m\u00e9todo de conectividad molecular para la b\u00fasqueda de relaciones cuantitativas estructura-actividad (rcea) y relaciones cuantitativas estructura-propiedad (rcep) con propiedades farmacocin\u00e9ticas, farmacodin\u00e1micas y fisicoqu\u00edmicas de un grupo heterog\u00e9neo de agentes hipoglucemiantes orales. La capacidad predictora de la mayor\u00eda de las funciones de conectividad obtenidas se puede considerar muy satisfactoria.  el an\u00e1lisis lineal discriminante, realizado al grupo objeto de estudio, ha resultado muy \u00fatil para clasificar los compuestos en funci\u00f3n de la actividad hipoglucemiante, alcanz\u00e1ndose una discriminaci\u00f3n superior al 85%.  en base a las propiedades limitantes se realiz\u00f3 la selecci\u00f3n molecular y los ensayos farmacol\u00f3gicos encaminados a corroborar la te\u00f3rica actividad hipoglucemiante. entre los productos que mostraron dicha actividad se encuentran: l-arabitol; azul \u00e1cido 161; 1,4-butanodiol diglicidil \u00e9ter y rojo \u00e1cido 151.  los resultados obtenidos confirman la validez del m\u00e9todo utilizado, por tratarse de una herramienta \u00fatil, tanto para la predicci\u00f3n de propiedades como para la b\u00fasqueda de nuevas estructuras con actividad hipoglucemiante.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicacion de la conectividad molecular para la busqueda de nuevos hipoglucemiantes orales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicacion de la conectividad molecular para la busqueda de nuevos hipoglucemiantes orales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Calabuig Ramon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ramon Garcia Domenech<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Moreno frigols <\/li>\n<li>esteban Morcillo sanchez (vocal)<\/li>\n<li>Miguel \u00e1ngel Miranda alonso (vocal)<\/li>\n<li>ernesto Estrada roger (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Calabuig Ramon Se ha aplicado el m\u00e9todo de conectividad molecular para la b\u00fasqueda de relaciones cuantitativas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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