{"id":40913,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-concentracion-de-la-melatonina-en-el-plasma-y-en-orina-a-lo-largo-de-las-24-horas-en-pacientes-con-enfermedad-de-parkinson-y-en-sujetos-controles\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-de-la-concentracion-de-la-melatonina-en-el-plasma-y-en-orina-a-lo-largo-de-las-24-horas-en-pacientes-con-enfermedad-de-parkinson-y-en-sujetos-controles","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-concentracion-de-la-melatonina-en-el-plasma-y-en-orina-a-lo-largo-de-las-24-horas-en-pacientes-con-enfermedad-de-parkinson-y-en-sujetos-controles\/","title":{"rendered":"Estudio de la concentracion de la melatonina en el plasma y en orina, a lo largo de las 24 horas, en pacientes con enfermedad de parkinson y en sujetos controles."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Ca\u00f1ete Nicolas <\/strong><\/h2>\n<p>El trabajo realizado ha consistido en el estudio de la hormona melatonina en la enfermedad de parkinson, y en sujetos controles sanos a lo largo del ritmo circadiano diario, es decir, a lo largo de las 24 horas, donde se ha demostrado un adelantamiento de la acrofase (nivel m\u00e1ximo) de melatonina situado entre las 20 y 24 horas en humanos, as\u00ed como confirmar tambi\u00e9n en humanos, los trabajos en animales de laboratorio realizado por otros autores donde existe un incremento exagerado de melatonina tras la ingesta de l-dopa. En pacientes de parkinson operados por palidotom\u00eda los niveles de melatonina disminuyeron coincidiendo \u00e9stos con la mejor\u00eda cl\u00ednica. Tambi\u00e9n se ha estudiado las actividades enzim\u00e1ticas super\u00f3xido dismutasa y monoamino oxidasa a lo largo de las 24 horas del d\u00eda, detect\u00e1ndose m\u00e1s actividad sod en pacientes de parkinson operados que en los no operados.  estos estudios circadianos han sido realizados por primera vez, siendo nuestro trabajo pionero en este tipo de estudio. Un hallazgo casual en el desarrollo de la tesis fue el encontrar cambios en los niveles de melatonina en pacientes con c\u00e1ncer de mama, coincidiendo \u00e9ste con el tipo y estadiaje del tumor, existiendo una relaci\u00f3n directa entre el grado de malignidad del tumor y la alteraci\u00f3n de las cifras de melatonina, que podr\u00eda tratarse de un buen marcador biol\u00f3gico de la malignidad del tumor de mama.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la concentracion de la melatonina en el plasma y en orina, a lo largo de las 24 horas, en pacientes con enfermedad de parkinson y en sujetos controles.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la concentracion de la melatonina en el plasma y en orina, a lo largo de las 24 horas, en pacientes con enfermedad de parkinson y en sujetos controles. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Ca\u00f1ete Nicolas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Catala Amoros M. Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Vi\u00f1a ribes <\/li>\n<li>federico Pallardo salcedo (vocal)<\/li>\n<li>Jos\u00e9 Luis Bardasano rubio (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Ca\u00f1ete Nicolas El trabajo realizado ha consistido en el estudio de la hormona melatonina en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,817,3919,965,156],"tags":[104029,104030,11454,17459,7414],"class_list":["post-40913","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-fisiologia-humana","category-neurofisiologia-humana","category-neuropatologia","category-patologia","tag-carlos-canete-nicolas","tag-catala-amoros-m-dolores","tag-federico-pallardo-salcedo","tag-jose-luis-bardasano-rubio","tag-jose-vina-ribes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40913"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40913\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40913"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40913"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}