{"id":40915,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/recuperacion-hematologica-despues-de-trasplante-autologo-de-sangre-periferica-en-pacientes-con-cancer-de-mama-de-alto-riesgo-de-recaida\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"recuperacion-hematologica-despues-de-trasplante-autologo-de-sangre-periferica-en-pacientes-con-cancer-de-mama-de-alto-riesgo-de-recaida","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/recuperacion-hematologica-despues-de-trasplante-autologo-de-sangre-periferica-en-pacientes-con-cancer-de-mama-de-alto-riesgo-de-recaida\/","title":{"rendered":"Recuperacion hematologica despues de trasplante autologo de sangre periferica en pacientes con cancer de mama de alto riesgo de recaida."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada Castillo Valero <\/strong><\/h2>\n<p>Debido al mal pron\u00f3stico de las pacientes con c\u00e1ncer de mama localmente avanzado (estadios ii y iii) se plantea tratamiento con quimioterapia a altas dosis (qad) seguido de trasplante aut\u00f3logo de progenitores hematopoy\u00e9ticos de sangre perif\u00e9rica.  objetivos: estudiar los factores implicados en la recuperaci\u00f3n hematol\u00f3gica (rh) precoz y tard\u00eda en 71 pacientes.  metodos: se analiza la celularidad obtenida despu\u00e9s de movilizaci\u00f3n con g-csf (10mcg\/kg) mediante c\u00e9lulas nucleadas, c\u00e9lulas cd34+ y cfu-gm. Se administr\u00f3 2 tipos de qad y 52 pacientes recibieron g-csf postrasplante (5mcg\/kg). se estudia el efecto de la cifra de cd34+ y de la administraci\u00f3n de g-csf en la rh y en las complicaciones y cuidados de soporte. adem\u00e1s se estudia el efecto de la radioterapia (rt) complementaria.  resultados: las c\u00e9lulas cd34+ y las subpoblaciones comprometidas cd34+\/cd13+ cd34+\/cd33+ cd34+\/cd38+ y cd34+\/hla-dr+ mostraron correlaci\u00f3n con la rh precoz. El g-csf acort\u00f3 el per\u00edodo de neutropenia \u00fanicamente en las pacientes con cd34+ menor de 4.5 millones\/kg.  las pacientes que recibieron una cifra de cd34+ superior a 5 millones\/kg mostraron un acortamiento significativo de la recuperaci\u00f3n plaquetar. Las complicaciones hematol\u00f3gicas y cuidados de soporte se redujeron en las pacientes con mayor cifra de cd34+ y en las que recibieron g-csf. El 60% presentaron infecciones generalmente bacteriemias por gram+.  confirmamos la evoluci\u00f3n ascendente de los recuentos hematim\u00e9tricos durante el a\u00f1o postrasplante salvo un descenso transitorio tras la rt (d\u00eda +90) especialmente en las pacientes con menor cifra de cd34+ reinfundida y en las que no recibieron g-csf. Las subpoblaciones menos comprometidas cd34+\/cd33- cd34+\/cd38- y cd34+\/hla-dr- no se correlacionaron con la rh tard\u00eda.  conclusiones:  el g-csf es un buen agente movilizador de progenitores hematopoy\u00e9ticos.  la determinaci\u00f3n por citofluorometr\u00eda de las cd34+ e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Recuperacion hematologica despues de trasplante autologo de sangre periferica en pacientes con cancer de mama de alto riesgo de recaida.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Recuperacion hematologica despues de trasplante autologo de sangre periferica en pacientes con cancer de mama de alto riesgo de recaida. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada Castillo Valero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Benet Monforte<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garc\u00eda conde bru javier <\/li>\n<li>Ana Villegas Martinez (vocal)<\/li>\n<li>\u00e1lvaro Urbano ispiz\u00faa (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Moraleda jim\u00e9nez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada Castillo Valero Debido al mal pron\u00f3stico de las pacientes con c\u00e1ncer de mama localmente avanzado (estadios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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