{"id":40924,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/actividad-mitocondrial-y-metabolismo-oxidativo-en-los-procesos-de-envejecimiento\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"actividad-mitocondrial-y-metabolismo-oxidativo-en-los-procesos-de-envejecimiento","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/actividad-mitocondrial-y-metabolismo-oxidativo-en-los-procesos-de-envejecimiento\/","title":{"rendered":"Actividad mitocondrial y metabolismo oxidativo en los procesos de envejecimiento."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Peiro Alos Celsa M. <\/strong><\/h2>\n<p>El estudio realizado consiste en el estudio del papel que juega la mitocondria y los ros en los mecanismos fisiol\u00f3gicos del envejecimiento. El estudio se llev\u00f3 a cabo en h\u00edgados de ratas de 6, 12 y 22 meses. Se estudi\u00f3 as\u00ed, el nivel energ\u00e9tico disponible por la c\u00e9lula mediante la determinaci\u00f3n de atp, que presenta una disminuci\u00f3n progresiva con la edad, debido a una alteraci\u00f3n en la funcionalidad de la cadena de transporte electr\u00f3nico, la cual estudiamos mediante la determinaci\u00f3n de la actividad succinato oxidasa, ascorbato \/tmpd oxidasa, glutamato\/malato oxidasa y citocromo oxidasa. El estudio de las alteraciones de la membrana mitocondrial con el envejecimiento, dio como resultado la presencia de mayor peroxidaci\u00f3n lip\u00eddica y una disminuci\u00f3n de la polaridad de membrana. Se determinaron mediante hplc los niveles de 8-oh-dg en dnat y dnamt, presentando mayores niveles de ambos con el envejecimiento. Se observ\u00f3 una disminuci\u00f3n de los niveles de antioxidantes (sod, cat, vit e y gsh) en el envejecimiento, sin embargo la gpx aumenta. En cambio, a los 12 meses de vida (coincidiendo con la etapa de la vida de m\u00e1xima actividad biol\u00f3gica) existe un mayor da\u00f1o oxidativo y unos menores niveles de antioxidantes, con lo cual la balanza oxidantes\/antioxidantes se inclinar\u00eda a favor de los segundos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad mitocondrial y metabolismo oxidativo en los procesos de envejecimiento.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad mitocondrial y metabolismo oxidativo en los procesos de envejecimiento. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Peiro Alos Celsa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guillermo Saez Tormo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Cabo soler <\/li>\n<li>pilar Mu\u00f1iz rodriguez (vocal)<\/li>\n<li>Jaime Miquel calatayud (vocal)<\/li>\n<li>teresa Barber sanchis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Peiro Alos Celsa M. El estudio realizado consiste en el estudio del papel que juega la mitocondria [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[922,160,35,32037,257,17],"tags":[12108,14632,11484,104051,27086,58098],"class_list":["post-40924","post","type-post","status-publish","format-standard","hentry","category-antropologia-fisica","category-bioquimica","category-ciencias-de-la-vida","category-envejecimiento-somatico","category-metabolismo-intermediario","category-quimica","tag-guillermo-saez-tormo","tag-jaime-miquel-calatayud","tag-jose-cabo-soler","tag-peiro-alos-celsa-m","tag-pilar-muniz-rodriguez","tag-teresa-barber-sanchis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40924"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40924\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40924"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}