{"id":40931,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/melanoma-maligno-estudio-del-marcador-de-proliferacion-celular-mib-1-y-su-correlacion-con-factores-pronosticos-y-evolucion\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"melanoma-maligno-estudio-del-marcador-de-proliferacion-celular-mib-1-y-su-correlacion-con-factores-pronosticos-y-evolucion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/melanoma-maligno-estudio-del-marcador-de-proliferacion-celular-mib-1-y-su-correlacion-con-factores-pronosticos-y-evolucion\/","title":{"rendered":"Melanoma maligno: estudio del marcador de proliferacion celular mib-1 y su correlacion con factores pronosticos y evolucion."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Quecedo Estebanez <\/strong><\/h2>\n<p>El melanoma maligno (mm) es un tumor en cuyo pron\u00f3stico han sido implicados numerosos factores cl\u00ednicos e histopatol\u00f3gicos. No obstante, en ocasiones muestra un comportamiento totalmente impredecible en funci\u00f3n de estos factores. El objetivo de este estudio fu\u00e9 analizar la expresi\u00f3n del marcador mib-1 en la progresi\u00f3n tumoral, en el pron\u00f3stico y la evoluci\u00f3n cl\u00ednica. Se seleccion\u00f3 217 lesiones melanoc\u00edticas: 64 nevus melanoc\u00edticos, 115 mm primarios y 40 met\u00e1stasis de mm. El marcador mib-1 se mostr\u00f3 en su cuantificaci\u00f3n y en su patr\u00f3n de distribuci\u00f3n como un significativo factor diferenciador de los 3 grupos, con valores significativamente ascendentes y predominio de su distribuci\u00f3n difusa conforme progresamos en malignidad. su \u00edndice y patr\u00f3n de distribuci\u00f3n tuvieron estrecha y directa correlaci\u00f3n con el espesor tumoral, nivel de clark, estad\u00edo cl\u00ednico y presencia de ulceraci\u00f3n y satelitosis. en t\u00e9rminos evolutivos, diferenci\u00f3 en diseminaci\u00f3n metast\u00e1sica y destino de la misma, as\u00ed como en supervivencia, tanto a corto como a largo plazo, confirmando su validez como factor pron\u00f3stico en todos los grupos de espesor tumoral, siendo un factor independiente y complementario del espesor de breslow.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Melanoma maligno: estudio del marcador de proliferacion celular mib-1 y su correlacion con factores pronosticos y evolucion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Melanoma maligno: estudio del marcador de proliferacion celular mib-1 y su correlacion con factores pronosticos y evolucion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Quecedo Estebanez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fortea Baixauli Jos\u00e9 Miguel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: adolfo Aliaga boniche <\/li>\n<li>Miguel angel Martorell cebollada (vocal)<\/li>\n<li>evaristo Sanchez yus (vocal)<\/li>\n<li>Carlos Ferr\u00e1ndiz foraster (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Quecedo Estebanez El melanoma maligno (mm) es un tumor en cuyo pron\u00f3stico han sido implicados numerosos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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