{"id":40938,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/administracion-intraventricular-aguda-y-cronica-de-valproato-en-un-modelo-de-epilepsia-farmacorresistente\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"administracion-intraventricular-aguda-y-cronica-de-valproato-en-un-modelo-de-epilepsia-farmacorresistente","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/administracion-intraventricular-aguda-y-cronica-de-valproato-en-un-modelo-de-epilepsia-farmacorresistente\/","title":{"rendered":"Administracion intraventricular aguda y cronica de valproato en un modelo de epilepsia farmacorresistente."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Serralta Serra Alfonso Juan <\/strong><\/h2>\n<p>Objetivo: determinar la eficacia anticonvulsivante, neurotoxocidad y concentraciones de f\u00e1rmaco en cerebro, l\u00edquido cefalorraqu\u00eddeo, plasma e h\u00edgado tras la inyecci\u00f3n aguda intraperitoneal, inyecci\u00f3n aguda intracerebroventricular y perfusi\u00f3n intracerebroventricular cont\u00ednua de \u00e1cido valproico en el modelo experimental de epilepsia farmacorresistencia por kindiling amigdalar en la rata.  material y m\u00e9todo: se inyectaron diferentes dosis de \u00e1cido valproico por v\u00eda intraperitoneal (200, 400 y 600 mg\/kg) y por v\u00eda intracerebroventricular (5, 15, 25, 35 mg\/kg) en ratas wistar macho. Se determin\u00f3 la concentraci\u00f3n de f\u00e1rmaco en el hemisferio cerebral ipsilateral a la inyecci\u00f3n, el hemisferio cerebral contralateral a la inyecci\u00f3n, el tronco cerebral y cerebelo, el l\u00edquido cefalorraqu\u00eddeo, el plasma y el h\u00edgado a distintos intervalos de tiempo tras la inyecci\u00f3n (15 y 30 minutos tras la inyecci\u00f3n intraperitoneal y 5 y 15 minutos tras la inyecci\u00f3n intracerebroventricular) mediante inmunofluorescencia. Las mismas dosis se inyectaron en ratas completamente kindlizadas y se test\u00f3 la eficacia anticonvulsivante del f\u00e1rmaco a los mismos tiempos de medida, midi\u00e9ndose la severidad de las crisis, la duraci\u00f3n de las crisis y de la postdescarga, la ataxia y la sedaci\u00f3n.  del mismo modo animales completamente kindlizados se perfundieron mediante bombas miniosm\u00f3ticas conectadas a cat\u00e9teres ventriculares, con una liberaci\u00f3n cont\u00ednua de 400 mg\/ml \u00e1cido valproico en soluci\u00f3n salina a tasas de 0.2, 0.4 y 0.8 mg\/h durante siete d\u00edas. Se determinaron diariamente el umbral de postdescarga, la latencia y duraci\u00f3n de las crisis, la duraci\u00f3n de la postdescarga y la neurotoxicidad antes, durante y en los tres d\u00edas posteriores a la perfusi\u00f3n. En animales de id\u00e9ntica edad y peso se infundi\u00f3 \u00e1cido valproico intracerebroventricular a las mismas dosis durante seis d\u00edas y se determinaron las concentraciones de f\u00e1rmaco en los dist<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Administracion intraventricular aguda y cronica de valproato en un modelo de epilepsia farmacorresistente.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Administracion intraventricular aguda y cronica de valproato en un modelo de epilepsia farmacorresistente. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Serralta Serra Alfonso Juan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Antonio Barcia Albacar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Barcia salorio Juan  Luis <\/li>\n<li>Jes\u00fas Vaquero crespo (vocal)<\/li>\n<li> Gil salu Jos\u00e9 Luis (vocal)<\/li>\n<li>Manuel Alos almi\u00f1ana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Serralta Serra Alfonso Juan Objetivo: determinar la eficacia anticonvulsivante, neurotoxocidad y concentraciones de f\u00e1rmaco en cerebro, l\u00edquido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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