{"id":40982,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/esofago-de-barrett-analisis-histopatologico-inmunohistoquimico-y-morfometrico-de-120-casos\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"esofago-de-barrett-analisis-histopatologico-inmunohistoquimico-y-morfometrico-de-120-casos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/esofago-de-barrett-analisis-histopatologico-inmunohistoquimico-y-morfometrico-de-120-casos\/","title":{"rendered":"Esofago de barrett: analisis histopatologico, inmunohistoquimico y morfometrico de 120 casos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Illueca Ballester <\/strong><\/h2>\n<p>En el es\u00f3fago de barrett el epitelio escamoso es reemplazado por un epitelio columnar. Los pacientes con es\u00f3fago de barrett presentan un mayor riesgo de adenocarcinoma. el objetivo del presente trabajo es la investigaci\u00f3n de t\u00e9cnicas que permitan identificar los pacientes con mayor riesgo de desarrollar c\u00e1ncer, y que por tanto necesitar\u00edan una vigilancia endosc\u00f3pica intensiva. se ha realizado un estudio morfol\u00f3gico, histoqu\u00edmico y morfom\u00e9trico sobre material bi\u00f3psico de 120 pacientes con es\u00f3fago de barrett y 18 con adenocarcinoma sobre es\u00f3fago de barrett. Cada muestra ha sido analizada inmunohistoqu\u00edmicamente, con los siguientes anticuerpos: pcna, p53, c-erbb-2 (neu\/her-2), cea y ema. Las pruebas estad\u00edsticas utilizadas han sido: el test de asociaci\u00f3n de la x de pearson, la prueba no param\u00e9trica de la u de mann-whitney y la prueba no param\u00e9trica de kruskal-wallis.  resultados: hemos encontrado un porcentaje mayor de n\u00facleos positivos para pcna cuando exist\u00eda metaplasia intestinal. un 94% de los adenocarcinomas expresaban pcna; hubo positividad para p53 en 15% de los casos sin displasia, en 37% de los casos con displasia y en el 44% de los adenocarcinomas; el c-erbb-2 fue positivo en 38% de los casos sin displasia, en 53% de las displasias y en un 37% de adenocarcinomas; las diferencias fueron estad\u00edsticamente significativas para p53. Encontramos aneuploidia en un 70% de casos con metaplasia o displasia, y en todos los adenocarcinomas, que en su mayor parte presentaron una cantidad de dna celular superior al valor triploide, a diferencia de los otros dos grupos (p&lt;0.001).  conclusiones:  1) la aneuploidia en valores cercanos al valor diploide, es decir, la hiperdiploidia, es muy frecuente en la metaplasia de barrett, y este hallazgo confirma que el es\u00f3fago de barrett es una condici\u00f3n premaligna.  2) la positividad para p53 se asocia con el proceso de transformaci\u00f3n maligna en el es\u00f3fago de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Esofago de barrett: analisis histopatologico, inmunohistoquimico y morfometrico de 120 casos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Esofago de barrett: analisis histopatologico, inmunohistoquimico y morfometrico de 120 casos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Illueca Ballester <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Llombart Bosch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: amando Peydro olaya <\/li>\n<li> Herrerias gutierrez Juan  Manuel (vocal)<\/li>\n<li>Francisco Martinez diaz (vocal)<\/li>\n<li> Serra desfilis Miguel angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Illueca Ballester En el es\u00f3fago de barrett el epitelio escamoso es reemplazado por un epitelio columnar. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,52,156],"tags":[26963,12285,104156,25202,11238,26813],"class_list":["post-40982","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-histopatologia","category-patologia","tag-amando-peydro-olaya","tag-antonio-llombart-bosch","tag-carmen-illueca-ballester","tag-francisco-Martinez-diaz","tag-herrerias-gutierrez-juan-manuel","tag-serra-desfilis-miguel-angel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40982"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40982\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40982"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}