{"id":40984,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-complejos-enzimaticos-histona-acetiltransferasa-en-saccharomyces-cerevisiae-mediante-el-uso-de-mutantes-en-genes-implicados-en-la-acetilacion-de-histonas\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"caracterizacion-de-complejos-enzimaticos-histona-acetiltransferasa-en-saccharomyces-cerevisiae-mediante-el-uso-de-mutantes-en-genes-implicados-en-la-acetilacion-de-histonas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-de-complejos-enzimaticos-histona-acetiltransferasa-en-saccharomyces-cerevisiae-mediante-el-uso-de-mutantes-en-genes-implicados-en-la-acetilacion-de-histonas\/","title":{"rendered":"Caracterizacion de complejos enzimaticos histona acetiltransferasa en saccharomyces cerevisiae mediante el uso de mutantes en genes implicados en la acetilacion de histonas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Belen Ruiz Garcia <\/strong><\/h2>\n<p>En la cromatina de eucariotas el dna se organiza alrededor de oct\u00e1meros de histonas, dando lugar a la estructura nucleosomal. Las histonas sufren una serie de modificaciones postraduccionales entre las que se encuentran la acetilaci\u00f3n de residuos de lisina, situados en los extremos n-terminales de estas prote\u00ednas. Esta modificaci\u00f3n reversible, catalizada in vivo por las histona acetiltransferasas (hat) y las histona desacetilasas (hd), ha sido implicada durante muchos a\u00f1os en la regulaci\u00f3n de diversos procesos celulares de gran importancia. Recientemente, el papel de la acetilaci\u00f3n de histonas en la regulaci\u00f3n de la transcripci\u00f3n ha cobrado gran importancia con el descubrimiento de que prote\u00ednas con actividad hat y hd son reguladores de la transcripci\u00f3n. En la levadura saccharomyces cerevisiae se han identificado los genes que codifican para cuatro prote\u00ednas con actividad hat, gcn5, hat1, esa1 y taf130. Mediante m\u00e9todos bioqu\u00edmicos se hab\u00eda detectado previamente la existencia en este organismo de al menos cuatro actividades histona acetiltransferasa diferentes, los enzimas hat a1, hat a2, hat a3 y hat b. el an\u00e1lisis bioqu\u00edmico de cepas de levadura mutantes en estos genes, y en otros genes que codifican prote\u00ednas relacionadas funcionalmente con estas hats, realizado en este trabajo, ha permitido caracterizar estos enzimas previamente descritos en cuanto a su composici\u00f3n en prote\u00ednas, su localizaci\u00f3n subcelular y su especificidad de sustrato. adem\u00e1s el estudio bioqu\u00edmico de cepas de levadura mutantes ha llevado a la identificaci\u00f3n de una nueva actividad histona acetiltransferasa no descrita hasta el momento, el enzima denominado hat a4.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion de complejos enzimaticos histona acetiltransferasa en saccharomyces cerevisiae mediante el uso de mutantes en genes implicados en la acetilacion de histonas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion de complejos enzimaticos histona acetiltransferasa en saccharomyces cerevisiae mediante el uso de mutantes en genes implicados en la acetilacion de histonas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Belen Ruiz Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ramon Sendra Perez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Franco vera <\/li>\n<li>enrique Palacian gil (vocal)<\/li>\n<li>pere Suau le\u00f3n (vocal)<\/li>\n<li>i. Georgieva elena (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Belen Ruiz Garcia En la cromatina de eucariotas el dna se organiza alrededor de oct\u00e1meros de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,36606,160,115,35,984,278,17],"tags":[104158,7149,104160,11638,13692,104159],"class_list":["post-40984","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-biologia-molecular-de-microorganismos","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-levaduras","category-microbiologia","category-quimica","tag-ana-belen-ruiz-garcia","tag-enrique-palacian-gil","tag-i-georgieva-elena","tag-luis-franco-vera","tag-pere-suau-leon","tag-ramon-sendra-perez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40984"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40984\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40984"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}