{"id":41086,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-de-moleculas-antiinflamatorias-de-origen-marino-inhibidores-de-fosfolipasas-a2\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-farmacologico-de-moleculas-antiinflamatorias-de-origen-marino-inhibidores-de-fosfolipasas-a2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-moleculas-antiinflamatorias-de-origen-marino-inhibidores-de-fosfolipasas-a2\/","title":{"rendered":"Estudio farmacologico de moleculas antiinflamatorias de origen marino, inhibidores de fosfolipasas a2."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Garcia Pastor <\/strong><\/h2>\n<p>El objeto de esta tesis doctoral ha sido doble, primero desarrollar una metodolog\u00eda in vivo e in vitro para el estudio de los diferentes mediadores que intervienen durante el proceso inflamatorio, y segundo, el estudio de un gran n\u00famero de moleculas de origen marino, naturales y semisint\u00e9ticas que se presentaban como potenciales inhibidores de la actividad fosfolipasa a2 (pla2). Dichos inhibidores presentaban en comun la estructura piranoflur\u00e1nica que se encuentra en conocidos inhibidores naturales de pla2 de origen marino, manoalida y lufolida. En este sentido cacospongionlida b y petrosaspongiolida m se han mostrado como potentes inhibidores irrreversibles de las pla2 secretoras del grupo ii y iii mostrando propiedades antiinflamatorias incluso tras administraci\u00f3n por via oral en diferentes modelos de inflamaci\u00f3n aguda y cr\u00f3nica, confirmando a este tipo de mol\u00e9culas como una v\u00eda alternativa para el desarrollo de nuevos f\u00e1rmacos antiinflamatorios.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacologico de moleculas antiinflamatorias de origen marino, inhibidores de fosfolipasas a2.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacologico de moleculas antiinflamatorias de origen marino, inhibidores de fosfolipasas a2. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Garcia Pastor <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Jos\u00e9 Alcaraz Tormo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 angel Fuentes cubero <\/li>\n<li>luigi Gomez-paloma (vocal)<\/li>\n<li>lisardo Bosc\u00e1 gomar (vocal)<\/li>\n<li>pilar Lopez garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Garcia Pastor El objeto de esta tesis doctoral ha sido doble, primero desarrollar una metodolog\u00eda in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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