{"id":41156,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-ultraestructural-de-la-composicion-de-las-celulas-de-paneth\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"analisis-ultraestructural-de-la-composicion-de-las-celulas-de-paneth","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-ultraestructural-de-la-composicion-de-las-celulas-de-paneth\/","title":{"rendered":"Analisis ultraestructural de la composicion de las celulas de paneth."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Olga Leis Gonzalez <\/strong><\/h2>\n<p>Las c\u00e9lulas de paneth se encuentran en el fondo de las gl\u00e1ndulas de lieberkuhn del intestino de mam\u00edferos. Su funci\u00f3n no es bien conocida, aunque se ha descrito que las c\u00e9lulas de paneth poseen un contenido heterog\u00e9neo que apunta hacia funciones muy distintas: desde la secreci\u00f3n de agentes antibacterianos, hasta el posible control de procesos de divisi\u00f3n en las criptas intestinales. A esto habr\u00eda que a\u00f1adir su posible relaci\u00f3n con las c\u00e9lulas caliciformes.  por esto planteamos los siguientes puntos de trabajo:  1) caracterizar y localizar ultraestructuralmente la composici\u00f3n oligosacar\u00eddica de las c\u00e9lulas de paneth utilizando lectinas combinadas con t\u00e9cnicas qu\u00edmicas y enzim\u00e1ticas de deglicosilaci\u00f3n.  2) caracterizar y localizar ultraestructuralmente los \u00abcores\u00bb proteicos de las glicoprote\u00ednas, mediante la utilizaci\u00f3n de anticuerpos anti-mucinas.  3) caracterizar y localizar ultraestructuralmente diferentes factores de crecimiento y sus receptores en las c\u00e9lulas de paneth. Para ello se utiliz\u00f3 anticuerpos anti-tgf-alfa, anti-egf y anti-egfr.  4) caracterizaci\u00f3n del proceso de desarrollo post-natal de las c\u00e9lulas de paneth, referido a la aparici\u00f3n de las mol\u00e9culas identificadas previamente en adultos.  tras analizar los resultados obtenidos se obtienen las siguientes conclusiones:  1) las c\u00e9lulas de paneth secretan glicoprote\u00ednas con cadenas oligosacar\u00eddicas de tipo n y de tipo o. La presencia de cadenas oligosacar\u00eddicas unidas por enlace o-glicos\u00eddico, t\u00edpico de c\u00e9lulas caliciformes, es un dato que permite hipotetizar sobre el origen c\u00f3mun de ambas c\u00e9lulas.  2) en las gl\u00e1ndulas intestinales se encuentran \u00abc\u00e9lulas intermedias\u00bb con gr\u00e1nulos de secreci\u00f3n semejantes a las c\u00e9lulas caliciformes, pero con una peque\u00f1a regi\u00f3n electrodensa que recuerda a las c\u00e9lulas de paneth. En esta regi\u00f3n se localiza la lisozima, componente caracter\u00edstico de las c\u00e9lulas de pane<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis ultraestructural de la composicion de las celulas de paneth.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis ultraestructural de la composicion de las celulas de paneth. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Olga Leis Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Madrid Cuevas Juan  Francisco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Miguel Ar\u00e9chaga mart\u00ednez <\/li>\n<li>Jorge Fernandez lopez-saez (vocal)<\/li>\n<li>Jos\u00e9 Ballesta german (vocal)<\/li>\n<li>agustin gregorio Zapata gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Olga Leis Gonzalez Las c\u00e9lulas de paneth se encuentran en el fondo de las gl\u00e1ndulas de lieberkuhn [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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