{"id":41202,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-infraccion-entre-via-4-yy-vcam-1-en-la-adhesion-del-melanoma-b16-a-la-estroma-medular-durante-la-metastasis-osea\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"implicacion-de-la-infraccion-entre-via-4-yy-vcam-1-en-la-adhesion-del-melanoma-b16-a-la-estroma-medular-durante-la-metastasis-osea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicacion-de-la-infraccion-entre-via-4-yy-vcam-1-en-la-adhesion-del-melanoma-b16-a-la-estroma-medular-durante-la-metastasis-osea\/","title":{"rendered":"Implicacion de la infraccion entre via-4 yy vcam-1 en la adhesion del melanoma b16 a la estroma medular durante la metastasis osea."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Hernandez Hernandez Jos\u00e9 Julio <\/strong><\/h2>\n<p>A pesar de la alta incidencia de met\u00e1stasis en la m\u00e9dula \u00f3sea de los pacientes con c\u00e1ncer, existe escasa informaci\u00f3n sobre su proceso patog\u00e9nico. Se ha sugerido que algunas mol\u00e9culas de adhesi\u00f3n celular implicadas en el tr\u00e1fico de c\u00e9lulas hematopoy\u00e9ticas podr\u00edan intervenir en la patog\u00e9nesis de las met\u00e1stasis cancerosas. una de \u00e9stas es la integrina alfa4beta1 (vla-4), cuyo aumento de expresi\u00f3n en algunos tumores humanos se ha correlacionado con el potencial metast\u00e1sico. Al igual que algunos melanomas humanos, el mb16 expresa constitutivamente la integrina vla-4. Sin embargo, se desconoce el mecanismo por el cu\u00e1l sus c\u00e9lulas pudieran metastatizar en m\u00e9dula \u00f3sea, a pesar de desprenderse del tumor primario gracias a la regulaci\u00f3n negativa de su vla-4.  de este modo, el presente trabajo se plantea para estudiar si la estroma de m\u00e9dula \u00f3sea (emo), activada por lps o el propio contacto con c\u00e9lulas del mb16, libera factores inductores de vla-4, que pudieran regular positivamente la adhesi\u00f3n del mb16 a la propia emo, a trav\u00e9s de vcam-1, promoviendo la formaci\u00f3n de met\u00e1stasis \u00f3seas.  a tal efecto, se determin\u00f3 in vivo el comportamiento metast\u00e1sico del mb16 pretratado con 1-desoximanojirimicina (1-dmm) tras su inoculaci\u00f3n en ratones normales, y del mb16 normal tras su inoculaci\u00f3n en ratones tratados con lps. Para estudiar la participaci\u00f3n de la il-1 en la formaci\u00f3n de met\u00e1stasis \u00f3seas, los ratones recibieron un antagonista del receptor de la il-1 (il-1ra; 5 mg\/kg, i.P.). Para determinar la implicaci\u00f3n de la vla-4, los ratones recibieron anticuerpos anti-vcam-1 (0,5 mg\/kg, i.V.). Asimismo, tras el establecimiento de cultivos de c\u00e9lulas de la emo enriquecidos en c\u00e9lulas endoteliales, se determin\u00f3 la implicaci\u00f3n de la interacci\u00f3n vla-4\/vcam-1 en la adhesi\u00f3n del mb16 a la emo-tratado o no con c\u00e9lulas de mb16 tratadas con 1-dmm fijadas-. En estos casos, las c\u00e9lulas del mb16 fueron pre-tratadas co<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicacion de la infraccion entre via-4 yy vcam-1 en la adhesion del melanoma b16 a la estroma medular durante la metastasis osea.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicacion de la infraccion entre via-4 yy vcam-1 en la adhesion del melanoma b16 a la estroma medular durante la metastasis osea. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Hernandez Hernandez Jos\u00e9 Julio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Vidal Vanaclocha<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li> Estrella ariguel Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>gregorio Garc\u00eda herdugo (vocal)<\/li>\n<li>anna Mar\u00eda Bassols teixido (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hernandez Hernandez Jos\u00e9 Julio A pesar de la alta incidencia de met\u00e1stasis en la m\u00e9dula \u00f3sea de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,1027,213,12909,156,2046],"tags":[13698,51461,12983,11100,104528,15059],"class_list":["post-41202","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-oncologia","category-osteopatologia","category-pais-vasco-euskal-herriko-unibertsitatea","category-patologia","category-radiologia","tag-anna-maria-bassols-teixido","tag-estrella-ariguel-jose-maria","tag-fernando-vidal-vanaclocha","tag-gregorio-garcia-herdugo","tag-hernandez-hernandez-jose-julio","tag-jesus-m-prieto-valtuena"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=41202"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41202\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=41202"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=41202"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=41202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}