{"id":41310,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evolucion-de-la-resistencia-de-s-pneumoniae-a-penicilina-y-macrolidos-en-301-cepas-clinicas-durante-1995-1996\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"evolucion-de-la-resistencia-de-s-pneumoniae-a-penicilina-y-macrolidos-en-301-cepas-clinicas-durante-1995-1996","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/evolucion-de-la-resistencia-de-s-pneumoniae-a-penicilina-y-macrolidos-en-301-cepas-clinicas-durante-1995-1996\/","title":{"rendered":"Evolucion de la resistencia de s. pneumoniae a penicilina y macrolidos en 301 cepas clinicas durante 1995-1996."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Navarro Pardos <\/strong><\/h2>\n<p>Se ha realizado el estudio de sensibilidad antimicrobiana de 301 cepas de s. Pneumoniae, obtenidas durante los a\u00f1os 1995-1996, frente a distintos antimicrobianos, por antibiograma y determinaci\u00f3n de c.I.M por el sistema pasco o el sistema e-test. Se ha obtenido 61,8% de cepas resistentes a penicilina, presentando 20,6% resistencia de alto nivel a la misma. La resistencia a eritromicina, tetraciclina, cloranfenicol, cotrimoxazol y ciprofloxacino ha sido de 30,9% 40,9%, 30,2%, 66,4% y 13,3% respectivamente. Se ha demostrado que la resistencia a penicilina se asocia significativamente con la resistencia a todos los antibi\u00f3ticos estudiados excepto ciprofloxacino. La actividad de las cefalosporinas de tercera y cuarta generaci\u00f3n como cefotaxima y cefepima se mantiene en las cepas con resistencia intermedia o de alto nivel a penicilina.  el estudio de los fenotipos de resistencia al grupo de los macr\u00f3lidos, lincosamidas y estreptograminas tipo b ha demostrado que el mecanismo de resistencia debido a modificaci\u00f3n de la diana, que da lugar al fenotipo de resistencia mlsb, por s\u00edntesis de metilasas que codifican los genes ermam es el m\u00e1s frecuente, siendo el fenotipo m de limitada preValencia. El sistema de eflujo implicado como responsable del fenotipo m se ha puesto de manifiesto mediante su inactivaci\u00f3n bloqueando el transporte con cccp. Los genes mef e son los determinantes gen\u00e9ticos del fenotipo m, caracterizado en neumococos, que puede coexistir de forma excepcional con el gen msr a\/b procedente de estafilococos.  en el an\u00e1lisis de los factores de riesgo asociados a la resistencia de s. pneumoniae a penicilina se realiz\u00f3 an\u00e1lisis bivariante y multivariante mediante regresi\u00f3n log\u00edstica demostrando que son estad\u00edsticamente significativos la administraci\u00f3n de betalact\u00e1micos previos y el antecedente de otitis.  a nivel hospitalario se ha comprobado que el consumo de macr\u00f3lidos ha aumentado durante el p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evolucion de la resistencia de s. pneumoniae a penicilina y macrolidos en 301 cepas clinicas durante 1995-1996.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evolucion de la resistencia de s. pneumoniae a penicilina y macrolidos en 301 cepas clinicas durante 1995-1996. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Navarro Pardos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Gomez Lus<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  jos\u00e9 Picazo de la garza <\/li>\n<li>Francisco Javier Suarez pinilla (vocal)<\/li>\n<li>Jos\u00e9 Prieto prieto (vocal)<\/li>\n<li>estrella Duran sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Navarro Pardos Se ha realizado el estudio de sensibilidad antimicrobiana de 301 cepas de s. Pneumoniae, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2193,35,278,13610],"tags":[104718,104719,11888,3474,3475,23553],"class_list":["post-41310","post","type-post","status-publish","format-standard","hentry","category-antibioticos","category-ciencias-de-la-vida","category-microbiologia","category-zaragoza","tag-carmen-navarro-pardos","tag-estrella-duran-sanchez","tag-francisco-javier-suarez-pinilla","tag-jose-prieto-prieto","tag-juan-jose-picazo-de-la-garza","tag-rafael-gomez-lus"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41310","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=41310"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41310\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=41310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=41310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=41310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}