{"id":41314,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-h-pylori-sobre-la-secrecion-de-pepsinogeno-en-celulas-pepticas-humanas\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"efecto-del-h-pylori-sobre-la-secrecion-de-pepsinogeno-en-celulas-pepticas-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-del-h-pylori-sobre-la-secrecion-de-pepsinogeno-en-celulas-pepticas-humanas\/","title":{"rendered":"Efecto del h. pylori sobre la secrecion de pepsinogeno en celulas pepticas humanas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sara Lorente Perez <\/strong><\/h2>\n<p>Diversas enfermedades gastroduodenales est\u00e1n relacionadas tanto con el incremento de la secreci\u00f3n g\u00e1strica como con la infecci\u00f3n por h. Pylori. Los mecanismos por los que h. Pylori es capaz de inducir da\u00f1o mucoso g\u00e1strico no est\u00e1n a\u00fan totalmente esclarecidos. Objetivos: determinar los efectos de h. pylori en la secreci\u00f3n de pepsin\u00f3geno en c\u00e9lulas p\u00e9pticas humanas aisladas in-vitro. M\u00e9todos: a partir de biopsias g\u00e1stricas humanas obtenidas mediante endoscopia, se realiz\u00f3 un proceso de separaci\u00f3n celular de acuerdo a un m\u00e9todo previamente descrito (scand j gastroenterol 1994; 29: 678-83). Las c\u00e9lulas p\u00e9pticas as\u00ed obtenidas se incubaron en al\u00edquotas de 10 5 durante 30 min. Y a 37 grados c, con las sustancias que fueron objeto de estudio. El pepsin\u00f3geno secretado se expresa como % (x+-se) del total de la enzima inicialmente presente en las c\u00e9lulas, e incremento sobre la secreci\u00f3n basal (%t-b). El tipaje de las cepas para el gen cag a se realiz\u00f3 mediante pcr est\u00e1ndar con primers espec\u00edficos. Resultados: h. Pylori (rango 10 6 -2&#215;10 7 u.F.C.) Increment\u00f3 la secreci\u00f3n basal de pepsin\u00f3geno de forma concentraci\u00f3n-dependiente (1%+-0.4-2.7%+-0.5;p&lt;0.01). Este est\u00edmulo no se observ\u00f3 con otras bacterias gram como e. coli (e. Coli 10 7 u.F.C.=0.2%+-0.2 vs h. Pylori 10 7 u.F.C.=1.2%+-0.4). Adem\u00e1s, h. Pylori produjo un aumento de la secreci\u00f3n p\u00e9ptica estimulada con histamina 10 -4m(hist. 10 -4m=1.9%+-0.4 vs hist. +5&#215;10 6 u.F.C.=3.2%+-0.5; p&lt;0.05) y ampc 10 -4m (0.8%+-0.2 vs 1.5%+-0.3; p&lt;0.05). Sin embargo, h. Pylori no afect\u00f3 a la secreci\u00f3n de pepsin\u00f3geno estimulada con carbacol (10 -5 -10 -7m) o cck (10 -6m). La adici\u00f3n de l-nmma (10 -3m), un inhibidor de la \u00f3xido n\u00edtrico-sintasa, redujo la secreci\u00f3n de pepsin\u00f3geno inducida por carbacol (carbacol 10 -5m = 2.5%+-0.5 vs carbacol 10 -5m + lnmma 10 -3m=0.8%+-0.4; p&lt;0.05) y por h. Pylori (10 7 u.F.C.=1%+-0.2 vs 10 7 u.F.C. + L-nmma 10 -3m=0.1%+-0<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del h. pylori sobre la secrecion de pepsinogeno en celulas pepticas humanas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del h. pylori sobre la secrecion de pepsinogeno en celulas pepticas humanas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sara Lorente Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Lanas Arbeloa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Ortego fernandez de retana <\/li>\n<li>daniel Boixeda de miquel (vocal)<\/li>\n<li> Castillo garcia Francisco j (vocal)<\/li>\n<li>Fernando Borda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sara Lorente Perez Diversas enfermedades gastroduodenales est\u00e1n relacionadas tanto con el incremento de la secreci\u00f3n g\u00e1strica como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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