{"id":41344,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/direccionamiento-celular-y-tumoral-con-secuencias-peptidicas-de-la-laminina-1-unidas-a-liposomas-estabilizados-que-encapsulan-doxorubicina\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"direccionamiento-celular-y-tumoral-con-secuencias-peptidicas-de-la-laminina-1-unidas-a-liposomas-estabilizados-que-encapsulan-doxorubicina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/direccionamiento-celular-y-tumoral-con-secuencias-peptidicas-de-la-laminina-1-unidas-a-liposomas-estabilizados-que-encapsulan-doxorubicina\/","title":{"rendered":"Direccionamiento celular y tumoral con secuencias peptidicas de la laminina-1 unidas a liposomas estabilizados que encapsulan doxorubicina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lopez Barcons LLuis Aristides <\/strong><\/h2>\n<p>Las c\u00e9lulas del fibrosarcoma humano ht-1080 presentan una elevada adhesi\u00f3n a la mol\u00e9cula de laminina-1 inmobilizada al soporte de pl\u00e1stico cuando se incuban a 37 grados c durante 30 min. Para averiguar cuales de las secuencias pept\u00eddicas de la laminina-1 estan implicadas en este efecto, se sintetizaron los p\u00e9ptidos yigsr y su p\u00e9ptido control peagd (lam2m). El p\u00e9ptido yigsr inmobilizado al mismo soporte causa la adhesi\u00f3n celular de manera dependiente de la concentraci\u00f3n de p\u00e9ptido inmobilizada y de forma significativa respecto de la obtenida con el p\u00e9ptido control. En forma soluble, en contacto con las c\u00e9lulas en suspensi\u00f3n inhibe la adhesi\u00f3n celular a la laminina-1 inmobilizada, de la misma manera, respecto de la obtenida con el p\u00e9ptido control. Se prepararon liposomas de composici\u00f3n epc\/epg\/col\/dspe-peg (28\/16\/50\/6). El p\u00e9ptido yigsr se uni\u00f3 covalentamente al derivado dspe-polietil\u00e9nglicol (peg). esta uni\u00f3n, no causa una disminuci\u00f3n de los efectos descritos anteriormente, lo que implica que las c\u00e9lulas ht-1080 tambi\u00e9n reconocen al p\u00e9ptido yigsr unido a liposoma. Se sintetizaron otros p\u00e9ptidos como el gysrarkeaasikvavsarkf (e(8)2-4-g), el rgd, el npwhsiyitrfg (ag-10) y su control, nidttdpeagdkdkdtgrglk (p5). Los p\u00e9ptidos e(8)2-4-g y ag-10 inmobilizados al mismo soporte, y a varias concentraciones, causaron la adhesi\u00f3n celular de forma significativa respecto de la obtenida con el p\u00e9ptido control p5. En forma soluble y en contacto con las c\u00e9lulas en suspensi\u00f3n, \u00fanicamente el primero inhibi\u00f3 la adhesi\u00f3n celular a la laminina-1 inmobilizada de forma significativa respecto del p\u00e9ptido control. Seguidamente, se encapsul\u00f3 doxorubicina (dox), en los liposomas descritos. El \u00ableakage\u00bb del f\u00e1rmaco encapsulado, ante varios medios, a 37 grado c, fue del 10%, pudiendose considerar a estos liposomas est\u00e9ricamente estabilizados (e.E.). El tratamiento de c\u00e9lulas ht-1080 durante 2 h a diferentes<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Direccionamiento celular y tumoral con secuencias peptidicas de la laminina-1 unidas a liposomas estabilizados que encapsulan doxorubicina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Direccionamiento celular y tumoral con secuencias peptidicas de la laminina-1 unidas a liposomas estabilizados que encapsulan doxorubicina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lopez Barcons LLuis Aristides <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angels Fabra Fres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: anna Mar\u00eda Bassols teixido <\/li>\n<li>Antonio Parente duena (vocal)<\/li>\n<li>Jos\u00e9 Portugal (vocal)<\/li>\n<li> Garcia anton Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lopez Barcons LLuis Aristides Las c\u00e9lulas del fibrosarcoma humano ht-1080 presentan una elevada adhesi\u00f3n a la mol\u00e9cula [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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