{"id":41361,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-farmacologicos-de-la-34-metilendioximetanfetamina-mdma-extasis-en-humanos\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"efectos-farmacologicos-de-la-34-metilendioximetanfetamina-mdma-extasis-en-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-farmacologicos-de-la-34-metilendioximetanfetamina-mdma-extasis-en-humanos\/","title":{"rendered":"Efectos farmacologicos de la 3,4 metilendioximetanfetamina (mdma, extasis) en humanos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Mas Garcia <\/strong><\/h2>\n<p>El \u00e9xtasis (3,4-metilendioximet\u00e1mfetamina, mdma) es un derivado anfetam\u00ednico de s\u00edntesis, cuyo consumo ha experimentado un gran auge en los \u00faltimos a\u00f1os entre los j\u00f3venes americanos y europeos. Existen muy pocos datos de su farmacolog\u00eda en humanos. Este estudio fue dise\u00f1ado para evaluar los efectos farmacol\u00f3gicos de la mdma. En \u00e9l participaron ocho varones sanos (consumidores recreacionales de mdma) siguiendo un dise\u00f1o doble-ciego, controlado, cruzado y aleatorizado. Las condiciones de tratamiento fueron placebo, mdma 75 y 125 mg y sulfato de anfetamina (snf)40 mg. Se administraron por v\u00eda oral y a dosis \u00fanica, en cuatro sesiones experimentales separadas por una semana.  las variables del estudio incluyeron medidas fisiol\u00f3gicas, rendimiento psicomotor, efectos subjetivos y par\u00e1metros farmacocin\u00e9ticos. La mdma y la anf produjeron un aumento en la presi\u00f3n arterial y la frecuencia card\u00edaca (esta \u00faltima con distinta secuencia temporal entre los dos f\u00e1rmacos), as\u00ed como un aumento del di\u00e1metro pupilar (mayor para la mdma). Las concentraciones plasm\u00e1ticas de cortisol aumentaron tras la administraci\u00f3n de ambas dosis de mdma, mientras que las de prolactina aumentaron s\u00f3lo tras la dosis alta de mdma. La hormona del crecimiento, no experiment\u00f3 cambios tras ninguno de los tratamientos. En el rendimiento psicomotor, la anf produjo una ligera mejor\u00eda respecto a placebo y la mdma 125 mg evidenci\u00f3 un ligero empeoramiento (dsst). La mdma 125 mg produjo mayores resultados en los efectos subjetivos indicativos de potencial de abuso (eav \u00abcolocado\u00bb, \u00able gusta el f\u00e1rmaco\u00bb, \u00abbuenos efectos\u00bb, arci-mbg (eufor\u00eda) que la anf o la mdma 75 mg. La mdma 125 indujo tambi\u00e9n cierto grado de sedaci\u00f3n y disforia(arci-pcag, arci-lsd y eav confusi\u00f3n). S\u00f3lo la mdma 125 mg produjo leves cambios en percepciones sensoriales visuales y auditivas. Las cmax observadas tras la administraci\u00f3n de mdma 125 y 75 mg fueron 236.4 y 130.9 ng\/ml, a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos farmacologicos de la 3,4 metilendioximetanfetamina (mdma, extasis) en humanos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos farmacologicos de la 3,4 metilendioximetanfetamina (mdma, extasis) en humanos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Mas Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mag\u00ed Farr\u00e9 Albaladejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi Cami morell <\/li>\n<li>Rafael De la torre fornell (vocal)<\/li>\n<li>ramon Miralles basseda (vocal)<\/li>\n<li>Marta Torrens melich (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Mas Garcia El \u00e9xtasis (3,4-metilendioximet\u00e1mfetamina, mdma) es un derivado anfetam\u00ednico de s\u00edntesis, cuyo consumo ha experimentado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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