{"id":41444,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-entre-los-factores-de-crecimiento-semejantes-a-insulina-y-las-metaloproteasas-de-matriz-en-proliferacion-e-invasion-tumoral\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"interaccion-entre-los-factores-de-crecimiento-semejantes-a-insulina-y-las-metaloproteasas-de-matriz-en-proliferacion-e-invasion-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/interaccion-entre-los-factores-de-crecimiento-semejantes-a-insulina-y-las-metaloproteasas-de-matriz-en-proliferacion-e-invasion-tumoral\/","title":{"rendered":"Interaccion entre los factores de crecimiento semejantes a insulina y las metaloproteasas de matriz en proliferacion e invasion tumoral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Santos Ma\u00f1es Broton <\/strong><\/h2>\n<p>La proliferaci\u00f3n celular es un proceso coordinado que implica la comunicaci\u00f3n celular a trav\u00e9s de mol\u00e9culas reguladoras conocidas como factores de crecimiento. Esta coordinaci\u00f3n se consigue a trav\u00e9s de loops autocrinos de factores mitog\u00e9nicos no espec\u00edficos de tejido como los igfs. Las c\u00e9lulas neopl\u00e1sicas se caracterizan por una relativa autonom\u00eda de crecimiento que podr\u00eda ser la consecuencia de la expresi\u00f3n constitutiva de igfs.  utilizando el adenocarcinoma humano du145 como modelo, se ha demostrado la existencia de un loop autocrino de igfs que regula la proliferaci\u00f3n de estas c\u00e9lulas. Este loop esta regulado por la secreci\u00f3n autocrina de la prote\u00edna de uni\u00f3n de igfs, igfbp3, y la metaloproteasa de matriz mmp9. Los resultados indican que la proliferaci\u00f3n autocrina de du145 es el resultado de la proteolisis regulada de igfbp3 por mmp9 a nivel de la membrana plasm\u00e1tica en estas c\u00e9lulas.  los igfs tambi\u00e9n est\u00e1n implicados en invasividad tumoral. Usando c\u00e9lulas mcf7, un carcinoma de mama humano, se ha demostrado que igfi coordina el aumento de actividad degradativa de matriz extracelular con la maquinaria responsable de motilidad celular. En este sentido la funci\u00f3n de igfi es doble: (i) aumenta la adhesi\u00f3n celular mediada por integrinas, y (ii) induce la defosforilaci\u00f3n de fak regulando el desensamblaje de las adhesiones focales. Esta \u00faltima funci\u00f3n la realiza activando la tirosina fosfatasa shp2, como se demuestra por la utilizaci\u00f3n de un mutante dominante negativo para esta enzima. La expresi\u00f3n del mutante de shp2 en du145 tambi\u00e9n disminuye la invasividad inducida por igfi en esta c\u00e9lulas. Ya que existe un loop autocrino operativo implicado en la proliferaci\u00f3n de du145, estos resultados sugieren que shp2 puede ser un punto de integraci\u00f3n de se\u00f1ales que controlan el crecimiento y la migraci\u00f3n celular. Tomados los datos en conjunto, se propone un modelo en el que la activaci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interaccion entre los factores de crecimiento semejantes a insulina y las metaloproteasas de matriz en proliferacion e invasion tumoral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interaccion entre los factores de crecimiento semejantes a insulina y las metaloproteasas de matriz en proliferacion e invasion tumoral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Santos Ma\u00f1es Broton <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Martinez Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel roman Benito de las heras <\/li>\n<li>Antonio Bernad miana (vocal)<\/li>\n<li>Carlos Lopez otin (vocal)<\/li>\n<li>josefa predestinaci\u00f3n Garc\u00eda ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Santos Ma\u00f1es Broton La proliferaci\u00f3n celular es un proceso coordinado que implica la comunicaci\u00f3n celular a trav\u00e9s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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