{"id":41451,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/senalizacion-celular-mediada-por-la-interaccion-de-la-integrina-vla-4-con-sus-ligandos-fn-cs-1-y-vcam-1\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"senalizacion-celular-mediada-por-la-interaccion-de-la-integrina-vla-4-con-sus-ligandos-fn-cs-1-y-vcam-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/senalizacion-celular-mediada-por-la-interaccion-de-la-integrina-vla-4-con-sus-ligandos-fn-cs-1-y-vcam-1\/","title":{"rendered":"Se\u00f1alizacion celular mediada por la interaccion de la integrina vla-4 con sus ligandos: fn (cs-1) y vcam-1."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Fernandez Villarreal Elena M. <\/strong><\/h2>\n<p>La integrina vla-4(alfa4beta1 elevada 2) est\u00e1 involucrada en procesos fisiol\u00f3gicos de importancia y en patolog\u00edas tan relevantes como en los procesos inflamatorios cr\u00f3nicos, asma, aterosclerosis, esclerosis m\u00faltiple y artritis reumatoide, as\u00ed como en la propagaci\u00f3n de determinados tumores. Un inter\u00e9s a\u00f1adido para el estudio de vla-4 es que es la \u00fanica integrina conocida capaz de mediar los dos tipos de interacciones, c\u00e9lula-c\u00e9lula, a trav\u00e9s de vcam-1, y c\u00e9lula-matriz extracelular a trav\u00e9s de fibronectina. Durante estos cuatro a\u00f1os de duraci\u00f3n de este proyecto, hemos intentado conocer y comprender las se\u00f1ales que la integrina vla-4 es capaz de producir en el interior de la c\u00e9lula en respuesta a la interacci\u00f3n con sus ligandos fibronectina y vcam-1.  en este sentido, uno de los primeros experimentos que llevarnos a cabo fue tratar de estudiar la fosforilaci\u00f3n de prote\u00ednas intracelulares en respuesta a la adhesi\u00f3n mediada por vla-4. observamos as\u00ed el incremento en la fosforilaci\u00f3n de una prote\u00edna de 100 kda capaz de co-precitipar con fak. \u00e9Sta podr\u00eda ser su sustrato. El conjunto de todos nuestros experimentos nos demostr\u00f3 que fak era capaz de activarse en la adhesi\u00f3n mediada por vla-4, y que su m\u00e1xima activaci\u00f3n ocurre a tiempos largos (60-90 minutos), tanto para fn 40 como para vcam-1. La activaci\u00f3n de fak podr\u00eda ser debida a la asociaci\u00f3n constitutiva entre fak y vla-4 que hemos observado.  al mismo tiempo la interacci\u00f3n de fak y p13-k en respuesta a la adhesi\u00f3n celular a trav\u00e9s de la integrina vla-4 tanto por experimentos de microscop\u00eda de fluorescencia como por inmunoprecipitaci\u00f3n va asociada a un incremento espec\u00edfico en la actividad de p13-k tras la adhesi\u00f3n celular a fn 40 y vcam-1, coincidiendo con los tiempos de m\u00e1xima actividad de la quinasa fak, los tiempos de m\u00e1xima adhesi\u00f3n celular y aquellos tiempos en los que se produce el spreading celular.  asimismo, hemos estudiado las posi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Se\u00f1alizacion celular mediada por la interaccion de la integrina vla-4 con sus ligandos: fn (cs-1) y vcam-1.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Se\u00f1alizacion celular mediada por la interaccion de la integrina vla-4 con sus ligandos: fn (cs-1) y vcam-1. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Fernandez Villarreal Elena M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Frailes M. Teresa De Los<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Mayor menendez <\/li>\n<li>angeles Garcia pardo (vocal)<\/li>\n<li>joaqu\u00edn Teixid\u00f3 calvo (vocal)<\/li>\n<li>Carlos Caba\u00f1as Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernandez Villarreal Elena M. La integrina vla-4(alfa4beta1 elevada 2) est\u00e1 involucrada en procesos fisiol\u00f3gicos de importancia y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[24373,105013,6285,105011,105012,24376],"class_list":["post-41451","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-angeles-garcia-pardo","tag-carlos-cabanas-Martinez","tag-federico-mayor-menendez","tag-fernandez-villarreal-elena-m","tag-frailes-m-teresa-de-los","tag-joaquin-teixido-calvo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41451","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=41451"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41451\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=41451"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=41451"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=41451"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}