{"id":41458,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-con-interferon-alfa-de-la-leucemia-mieloide-ph1-positiva-en-su-fase-cronica\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"tratamiento-con-interferon-alfa-de-la-leucemia-mieloide-ph1-positiva-en-su-fase-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tratamiento-con-interferon-alfa-de-la-leucemia-mieloide-ph1-positiva-en-su-fase-cronica\/","title":{"rendered":"Tratamiento con interferon alfa de la leucemia mieloide ph1-positiva en su fase cronica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Luis Steegmann Olmedillas <\/strong><\/h2>\n<p>Objetivos del estudio. An\u00e1lisis de la eficacia del ifn alfa en la fase cr\u00f3nica de la lmc ph1 positiva. dise\u00f1o del estudio.- Estudio prospectivo de \u00fanica rama, sin grupo control. Pacientes.- Se incluyeron 132 pacientes, 72 hombres y 60 mujeres. Mediana de edad: 43 a\u00f1os (12,2 &#8211; 79,4). Estadios (sokal): 1(br): 52 %, 2(ri): 26%, 3 (ar): 20%. M\u00e9todos estad\u00edsticos. Incluyeron regresi\u00f3n log\u00edstica y modelos de regresi\u00f3n de cos. Esquema de tratamiento: la hidroxiurea se utilizaba para descender la cifra de leucocitos al intervalo de 15-20 x 10 elevado a 9\/l, momento en el que se suspend\u00eda y se comenzaba al ifn alfa, como \u00fanico tratamiento. Esto ocurri\u00f3 un 67% de los pacientes. Un 30% de los pacientes comenzaron directamente con ifn alfa. Posolog\u00eda: 3 mu\/d\/s.C. La 1a semana, 6 mu\/d\/s.C., La 2a y 9 mu\/d\/s.C. La 3a y siguientes. Dosis recibida: 5,8 mu\/d. Tiempo de tratamiento: 431 d\u00edas (rango: 18-2597). Respuesta hematol\u00f3gica (rh) y citogen\u00e9tica (rg): un 72% obtuvo rh en el primer semestre del tratamiento. Un 47% de pacientes obtuvo rg: fueron mayores el 27% (19% completas). La mediana de obtenci\u00f3n de rg fue de 7, 9 y 18 meses para la rgm, rgp y rgc, respectivamente. El an\u00e1lisis multivariante demostr\u00f3 que un mayor porcentaje de bas\u00f3filos se asociaba a peor respuesta hematol\u00f3gica (p=0,001) (or: 1,23) y a una peor respuesta gen\u00e9tica en el primer a\u00f1o (p=0,018) (or:1,4). Toxicidad. Un 13% de los pacientes tuvieron que abandonar el estudio, por efectos secundarios (m\u00e1s frecuentes: s. Pseudogripal y parkinsonismo). La toxicidad cr\u00f3nica m\u00e1s frecuente fue la hematol\u00f3gica. supervivencia. En el per\u00edodo de observaci\u00f3n de 8 a\u00f1os y tres meses han fallecido un 35,6% y continuaban vivos 85 pacientes (64,4%), conmediana de seguimiento de 42 meses (3,7 &#8211; 98). Las probabilidades de supervivencia (sg) y supervivencia libre de transformaci\u00f3n (slt) a los seis a\u00f1os han sido de 0,61+-0,07 y 0,54+-0,07. Las variables asociadas co<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento con interferon alfa de la leucemia mieloide ph1-positiva en su fase cronica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento con interferon alfa de la leucemia mieloide ph1-positiva en su fase cronica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Luis Steegmann Olmedillas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Sanchez Fayos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garc\u00eda Conde Bru Javier <\/li>\n<li>Rogelio Gonzalez Sarmiento (vocal)<\/li>\n<li>Manuel Serrano Rios (vocal)<\/li>\n<li>Felix Carbonell Ramon (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Luis Steegmann Olmedillas Objetivos del estudio. An\u00e1lisis de la eficacia del ifn alfa en la fase [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,9,189,218,195,139,156],"tags":[39952,11726,30138,85725,5694,26315],"class_list":["post-41458","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","category-hematologia","category-hemopatologia","category-medicina-interna","category-patologia","tag-felix-carbonell-ramon","tag-garcia-conde-bru-javier","tag-jose-sanchez-fayos","tag-juan-luis-steegmann-olmedillas","tag-manuel-serrano-rios","tag-rogelio-gonzalez-sarmiento"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41458","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=41458"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41458\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=41458"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=41458"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=41458"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}