{"id":41488,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-funcional-de-la-proteina-6k-de-alfa-virus-el-virus-sindbis-como-vector-de-expresion\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"caracterizacion-funcional-de-la-proteina-6k-de-alfa-virus-el-virus-sindbis-como-vector-de-expresion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-funcional-de-la-proteina-6k-de-alfa-virus-el-virus-sindbis-como-vector-de-expresion\/","title":{"rendered":"Caracterizacion funcional de la proteina 6k de alfa virus. el virus sindbis como vector de expresion."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Angel Sanz Fernandez <\/strong><\/h2>\n<p>Las prote\u00ednas 6k del sfv y del sv son capaces de inducir cambios de permeabilidad a higromicina b cuando se sintetizan, tanto en bacterias como en c\u00e9lulas de mam\u00edfero. Un mutante de deleci\u00f3n en 6k del sv presenta defectos en el procesamiento de la poliprote\u00edna precursora de las glicoprote\u00ednas virales. este defecto va acompa\u00f1ado de cambios en la maduraci\u00f3n y transporte a membrana celular de las glicoprote\u00ednas virales que le hacen inviable. psudorevertientes viables de este mutante presentan un procesamiento del precursor similar al wt, pero a\u00fan difieren de \u00e9ste por su fenotipo de placa peque\u00f1a. La complementaci\u00f3n de los pseudorevertientes con una 6k genuina expresada en trans no revierte el fenotipo de placa peque\u00f1a. Los replicones dise\u00f1ados, basados en el genoma del sv que expresan \u00abc + prote\u00edna heter\u00f3loga\u00bb permiten una s\u00edntesis abundante de prote\u00ednas recombinantes en c\u00e9lulas de mam\u00edfero. Estos replicones permiten un an\u00e1lisis r\u00e1pido y eficaz de los cambios de permeabilidad de las prote\u00ednas heter\u00f3logas. se ha clonado el genoma completo del virus de la polio dentro de un replic\u00f3n del sv. El estudio de mutantes no viables del virus de la polio se ve facilitado por el empleo de este replic\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion funcional de la proteina 6k de alfa virus. el virus sindbis como vector de expresion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion funcional de la proteina 6k de alfa virus. el virus sindbis como vector de expresion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Angel Sanz Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Carrasco Llamas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda no Esteban rodriguez <\/li>\n<li>Miguel angel Alonso lebrero (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Almendral del rio (vocal)<\/li>\n<li> Nieva escandon Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Angel Sanz Fernandez Las prote\u00ednas 6k del sfv y del sv son capaces de inducir cambios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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