{"id":41587,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-por-el-tnf-alfa-de-la-interaccion-de-proteinas-citosolicas-de-neutrofilos-humanos-con-el-arnm-de-la-oxido-nitrico-sintasa-endotelial-aplicacion-en-el-infarto-agudo-de-miocardio-iam\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"regulacion-por-el-tnf-alfa-de-la-interaccion-de-proteinas-citosolicas-de-neutrofilos-humanos-con-el-arnm-de-la-oxido-nitrico-sintasa-endotelial-aplicacion-en-el-infarto-agudo-de-miocardio-iam","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/regulacion-por-el-tnf-alfa-de-la-interaccion-de-proteinas-citosolicas-de-neutrofilos-humanos-con-el-arnm-de-la-oxido-nitrico-sintasa-endotelial-aplicacion-en-el-infarto-agudo-de-miocardio-iam\/","title":{"rendered":"Regulacion por el tnf-alfa de la interaccion de proteinas citosolicas de neutrofilos humanos con el arnm de la oxido nitrico sintasa endotelial. aplicacion en el infarto agudo de miocardio (iam)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Gomez Octavio <\/strong><\/h2>\n<p>El \u00f3xido n\u00edtrico es un gas generado por diversas c\u00e9lulas, entre ellas el endotelio y los neutrofilos. es importante puesto que regula la interacci\u00f3n celular y molecular en diversas patolog\u00edas cardiovasculares como los s\u00edndromes coronarios agudos. cuando existe alteraci\u00f3n en la acci\u00f3n del no desde el endotelio, se dice que existe disfunci\u00f3n endotelial. el conocimiento de la regulaci\u00f3n de este mecanismo puede ser fundamental. En esta tesis se confirma la existencia del enzima \u00f3xido n\u00edtrico sintasa endotelial (nose) en neutrofilos humanos. Adem\u00e1s se observa que el tnf-alfa, como citoquina proinflamatoria, induce una menor expresi\u00f3n de nose, a trav\u00e9s de una desestabilizaci\u00f3n del arn mensajero de la nose, debido a la aparici\u00f3n de unas prote\u00ednas citosolicas que se unen a una regi\u00f3n espec\u00edfica del arnm, degenerandolo. Esta situaci\u00f3n se observa en el infarto agudo de miocardio, situaci\u00f3n donde se da una acci\u00f3n inflamatoria..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion por el tnf-alfa de la interaccion de proteinas citosolicas de neutrofilos humanos con el arnm de la oxido nitrico sintasa endotelial. aplicacion en el infarto agudo de miocardio (iam).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion por el tnf-alfa de la interaccion de proteinas citosolicas de neutrofilos humanos con el arnm de la oxido nitrico sintasa endotelial. aplicacion en el infarto agudo de miocardio (iam). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Gomez Octavio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio L\u00f3pez Farr\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Oya otero <\/li>\n<li>david Garcia-dorada garcia (vocal)<\/li>\n<li>Juan  Luis Tamargo men\u00e9ndez (vocal)<\/li>\n<li>Mar\u00eda  monica De la fuente del rey (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Gomez Octavio El \u00f3xido n\u00edtrico es un gas generado por diversas c\u00e9lulas, entre ellas el endotelio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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