{"id":41595,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-un-modelo-experimental-de-preeclampsia-sobre-la-reactividad-vascular-de-ratas-gestantes-y-de-sus-crias-fetales-y-neonatales\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"efectos-de-un-modelo-experimental-de-preeclampsia-sobre-la-reactividad-vascular-de-ratas-gestantes-y-de-sus-crias-fetales-y-neonatales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-un-modelo-experimental-de-preeclampsia-sobre-la-reactividad-vascular-de-ratas-gestantes-y-de-sus-crias-fetales-y-neonatales\/","title":{"rendered":"Efectos de un modelo experimental de preeclampsia sobre la reactividad vascular de ratas gestantes y de sus crias fetales y neonatales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Antonio Martinez Orgado <\/strong><\/h2>\n<p>Un grupo de 20 ratas wistar pre\u00f1adas recibieron oralmente el inhibidor de la sintasa de xido n\u00edtrico (nos) ng-nitro-l-argimin metilester (l-name) del 10 al 21 d\u00eda de gestaci\u00f3n, lo que indujo un cuadro similar a la preeclampsia. El estudio \u00abin vitro\u00bb de segmentos a\u00f3rticos de estas ratas demostr\u00f3 una reducci\u00f3n del 30% en la vasodilataci\u00f3n dependiente de endotelio inducida por acetilcolina (ach) 10 um, en comparaci\u00f3n con la obtenida de un grupo de 16 ratas pre\u00f1adas control. El tratamiento de un grupo de 14 ratas v\u00edrgenes con l-name 10 d\u00edas, o de 10 ratas pu\u00e9rperas del 10 d\u00eda de gestaci\u00f3n al 2 d\u00eda postparto, en cambio, no implic\u00f3 ninguna modificaci\u00f3n en la respuesta vasodilatadora, en comparaci\u00f3n con la de 12 ratas v\u00edrgenes y 9 pu\u00e9rperas no tratadas. La menor respuesta en ratas gestantes hipertensas se debi\u00f3 a una mayor afectaci\u00f3n de la actividad de la nos, y al fracaso de una compensaci\u00f3n mediante mecanismos hiperpolarizantes, como s\u00ed ocurri\u00f3 en ratas no pre\u00f1adas. Estas diferencias sugieren la existencia de alg\u00fan(os) factor(es) presente(s) en ratas gestantes hipertensas que inducir\u00eda(n) una disfunci\u00f3n endotelial. Al estudiar la vasodilataci\u00f3n inducida por ach 1 um en las cr\u00edas, se obsev\u00f3 una reducci\u00f3n del 25% en fetos de ratas tratadas frente a controles, mientras que no hubo reducci\u00f3n de la respuesta en cr\u00edas reci\u00e9n nacidas, debido a una mayor resistencia a la acci\u00f3n inhibitoria de l-name. Estas diferencias sugieren que el(los) factor(es) presente(s) en la rata gestante tambi\u00e9n inducir\u00eda(n) una disfunci\u00f3n endotelial en el feto..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de un modelo experimental de preeclampsia sobre la reactividad vascular de ratas gestantes y de sus crias fetales y neonatales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de un modelo experimental de preeclampsia sobre la reactividad vascular de ratas gestantes y de sus crias fetales y neonatales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Antonio Martinez Orgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Marin Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>bartolome Bonet serra (vocal)<\/li>\n<li>mercedes Salaios sanchez (vocal)<\/li>\n<li>gloria Balfajain calvo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Antonio Martinez Orgado Un grupo de 20 ratas wistar pre\u00f1adas recibieron oralmente el inhibidor de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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